Thymidylate 5'-phosphatase

From Wikipedia, the free encyclopedia

In enzymology, a thymidylate 5'-phosphatase (EC 3.1.3.35) is an enzyme that catalyzes the chemical reaction

thymidylate + H₂O thymidine + phosphate

Thus, the two substrates of this enzyme are thymidylate and H₂O, whereas its two products are thymidine and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is thymidylate 5'-phosphohydrolase. Other names in common use include thymidylate 5'-nucleotidase, deoxythymidylate 5'-nucleotidase, thymidylate nucleotidase, deoxythymidylic 5'-nucleotidase, deoxythymidylate phosphohydrolase, and dTMPase.

[edit] References

• IUBMB entry for 3.1.3.35
• BRENDA references for 3.1.3.35 (Recommended.)
• PubMed references for 3.1.3.35
• PubMed Central references for 3.1.3.35
• Google Scholar references for 3.1.3.35
• Aposhian HV, Tremblay GY (1966). "Deoxythymidylate 5'-nucleotidase. Purification and properties of an enzyme found after infection of Bacillus subtilis with phage SP5C". J. Biol. Chem. 241: 5095–101. PMID 4958986. 

[edit] External links

The CAS registry number for this enzyme class is 9026-80-6.

• IUBMB entry for 3.1.3.35

• KEGG entry for 3.1.3.35

• BRENDA entry for 3.1.3.35

• NiceZyme view of 3.1.3.35

• EC2PDB: PDB structures for 3.1.3.35

• PRIAM entry for 3.1.3.35

• PUMA2 entry for 3.1.3.35

• IntEnz: Integrated Enzyme entry for 3.1.3.35

• MetaCyc entry for 3.1.3.35

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050340: thymidylate 5'-phosphatase

• AMIGO entry for GO code 0050340: thymidylate 5'-phosphatase