Thymidine phosphorylase

From Wikipedia, the free encyclopedia

In enzymology, a thymidine phosphorylase (EC 2.4.2.4) is an enzyme that catalyzes the chemical reaction

thymidine + phosphate thymine + 2-deoxy-alpha-D-ribose 1-phosphate

Thus, the two substrates of this enzyme are thymidine and phosphate, whereas its two products are thymine and 2-deoxy-alpha-D-ribose 1-phosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is thymidine:phosphate deoxy-alpha-D-ribosyltransferase. Other names in common use include pyrimidine phosphorylase, thymidine-orthophosphate deoxyribosyltransferase, animal growth regulators, blood platelet-derived endothelial cell, growth factors, blood platelet-derived endothelial cell growth factor, deoxythymidine phosphorylase, gliostatins, pyrimidine deoxynucleoside phosphorylase, and thymidine:phosphate deoxy-D-ribosyltransferase. This enzyme participates in 3 metabolic pathways: purine metabolism, pyrimidine metabolism, and bladder cancer.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1AZY, 1OTP, 1TPT, 1UOU, 2J0F, and 2TPT.

[edit] References

• IUBMB entry for 2.4.2.4
• BRENDA references for 2.4.2.4 (Recommended.)
• PubMed references for 2.4.2.4
• PubMed Central references for 2.4.2.4
• Google Scholar references for 2.4.2.4
• FRIEDKIN M, ROBERTS D (1954). "The enzymatic synthesis of nucleosides. I. Thymidine phosphorylase in mammalian tissue". J. Biol. Chem. 207: 245–56. PMID 13152099. 
• Zimmerman M and Seidenberg J (1964). "Deoxyribosyl transfer. I. Thymidine phosphorylase and nucleoside deoxyribosyltransferase in normal and malignant tissues". J. Biol. Chem. 239: 2618–2621. 
• Zimmerman M (1964). "Deoxyribosyl transfer. II. Nucleoside:pyrimidine deoxyribosyltransferase activity of three partially purified thymidine phosphorylases". J. Biol. Chem. 239: 2622–2627. 

[edit] External links

The CAS registry number for this enzyme class is 9030-23-3.

• IUBMB entry for 2.4.2.4

• KEGG entry for 2.4.2.4

• BRENDA entry for 2.4.2.4

• NiceZyme view of 2.4.2.4

• EC2PDB: PDB structures for 2.4.2.4

• PRIAM entry for 2.4.2.4

• PUMA2 entry for 2.4.2.4

• IntEnz: Integrated Enzyme entry for 2.4.2.4

• MetaCyc entry for 2.4.2.4

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0009032: thymidine phosphorylase

• AMIGO entry for GO code 0009032: thymidine phosphorylase