Thymidine kinase 1

From Wikipedia, the free encyclopedia

Thymidine kinase 1, soluble

PDB rendering based on 1w4r.

Available structures: 1w4r, 1xbt, 2orv

Identifiers

Symbol(s)

TK1; TK2

External IDs

OMIM: 188300 MGI: 98763 HomoloGene: 37749

Gene ontology
Molecular Function:	• nucleotide binding • thymidine kinase activity • ATP binding • kinase activity • transferase activity
Cellular Component:	• cytoplasm
Biological Process:	• nucleobase, nucleoside, nucleotide and nucleic acid metabolic process • DNA replication

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_003258 (mRNA)
NP_003249 (protein)

NM_009387 (mRNA)
NP_033413 (protein)

Location

Chr 17: 73.68 - 73.69 Mb

n/a

Pubmed search

[1]

[2]

Thymidine kinase 1, soluble (gene name TK1), is a human thymidine kinase.^[1]

Two forms of this protein have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells.

[edit] References

^ Entrez Gene: Thymidine kinase 1, soluble.

[edit] Further reading

Kim YK, Lee AS (1992). "Identification of a protein-binding site in the promoter of the human thymidine kinase gene required for the G1-S-regulated transcription.". J. Biol. Chem. 267 (4): 2723–7. PMID 1370831.
Barik S, Banerjee AK (1991). "Cloning and expression of the vesicular stomatitis virus phosphoprotein gene in Escherichia coli: analysis of phosphorylation status versus transcriptional activity.". J. Virol. 65 (4): 1719–26. PMID 1848304.
Sadava D, Bernard B (1991). "Transition from cytosolic to mitochondrial thymidine kinase during development in human fetal tissues.". Life Sci. 47 (25): 2359–64. PMID 2263164.
Tamiya N, Yusa T, Yamaguchi Y, et al. (1989). "Co-purification of thymidylate kinase and cytosolic thymidine kinase from human term placenta by affinity chromatography.". Biochim. Biophys. Acta 995 (1): 28–35. PMID 2538159.
Slagel V, Flemington E, Traina-Dorge V, et al. (1988). "Clustering and subfamily relationships of the Alu family in the human genome.". Mol. Biol. Evol. 4 (1): 19–29. PMID 3128713.
Flemington E, Bradshaw HD, Traina-Dorge V, et al. (1987). "Sequence, structure and promoter characterization of the human thymidine kinase gene.". Gene 52 (2-3): 267–77. PMID 3301530.
Sherley JL, Kelly TJ (1988). "Human cytosolic thymidine kinase. Purification and physical characterization of the enzyme from HeLa cells.". J. Biol. Chem. 263 (1): 375–82. PMID 3335503.
Kreidberg JA, Kelly TJ (1987). "Genetic analysis of the human thymidine kinase gene promoter.". Mol. Cell. Biol. 6 (8): 2903–9. PMID 3785218.
Bradshaw HD, Deininger PL (1985). "Human thymidine kinase gene: molecular cloning and nucleotide sequence of a cDNA expressible in mammalian cells.". Mol. Cell. Biol. 4 (11): 2316–20. PMID 6549046.
Kuo WL, Hirschhorn R, Huie ML, Hirschhorn K (1996). "Localization and ordering of acid alpha-glucosidase (GAA) and thymidine kinase (TK1) by fluorescence in situ hybridization.". Hum. Genet. 97 (3): 404–6. PMID 8786092.
Chang ZF, Huang DY, Chi LM (1998). "Serine 13 is the site of mitotic phosphorylation of human thymidine kinase.". J. Biol. Chem. 273 (20): 12095–100. PMID 9575153.
Berenstein D, Christensen JF, Kristensen T, et al. (2000). "Valine, not methionine, is amino acid 106 in human cytosolic thymidine kinase (TK1). Impact on oligomerization, stability, and kinetic properties.". J. Biol. Chem. 275 (41): 32187–92. doi:10.1074/jbc.M005325200. PMID 10924519.
Huang DY, Chang ZF (2001). "Interaction of human thymidine kinase 1 with p21(Waf1).". Biochem. J. 356 (Pt 3): 829–34. PMID 11389691.
Fujiwaki R, Hata K, Moriyama M, et al. (2001). "Clinical value of thymidine kinase in patients with cervical carcinoma.". Oncology 61 (1): 47–54. PMID 11474248.
Fujiwaki R, Hata K, Nakayama K, et al. (2002). "Thymidine kinase in epithelial ovarian cancer: relationship with the other pyrimidine pathway enzymes.". Int. J. Cancer 99 (3): 328–35. doi:10.1002/ijc.10319. PMID 11992400.
Mao Y, Wu J, Wang N, et al. (2002). "A comparative study: immunohistochemical detection of cytosolic thymidine kinase and proliferating cell nuclear antigen in breast cancer.". Cancer Invest. 20 (7-8): 922–31. PMID 12449723.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gilles SI, Romain S, Casellas P, et al. (2003). "Mutation analysis in the coding sequence of thymidine kinase 1 in breast and colorectal cancer.". Int. J. Biol. Markers 18 (1): 1–6. PMID 12699056.
Han T, Fernandez M, Sarkar M, Agarwal RP (2004). "2', 3'-Dideoxycytidine represses thymidine kinases 1 and 2 expression in T-lymphoid cells.". Life Sci. 74 (7): 835–42. PMID 14659972.
Li CL, Lu CY, Ke PY, Chang ZF (2004). "Perturbation of ATP-induced tetramerization of human cytosolic thymidine kinase by substitution of serine-13 with aspartic acid at the mitotic phosphorylation site.". Biochem. Biophys. Res. Commun. 313 (3): 587–93. PMID 14697231.