Talk:Thyroid

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Peer review This article was externally reviewed (December 14, 2005) by Nature. It was found to have 7 errors.

Contents

[edit] References

This article is in dire need of references. Could you state your sources ? Books would be very welcome for an article like this.

Much of it is collated from web pages. I thought I should expand the article a bit. There must be good book sources, but I hate my physiology textbook so much I would never use it as a reference :-) JFW | T@lk 22:07, 1 November 2005 (UTC)

Thanks for this article. I suggest mentioning that the effects of changes in metablism impact on all parts of the body including activity/energy level, weight, thought process, skin/hair growth, feeling hot/cold etc. etc. etc. In terms of treatment, worth repeating that levothyronine should replace natural production of t4 and t3 because the "free" element is regulated in the blood and liver.

For references for the lay user: British Medical Association book Coping with Thyroid Illness.

[edit] list of errors found and fixed

Listing of errors found and removed after Nature review beginning 12/14/05. Please add only clear errors of fact rather than editorial or language improvement. I have only reviewed a few paragraphs so far and will look up some more things. alteripse 12:18, 15 December 2005 (UTC)

  1. thyroid is not largest gland, pancreas and often the testes are larger in mass and volume; (and this is not even counting the non-classical endocrine glands like the brain, heart, liver, intestines, adipose, kidneys etc)
  2. normal adult size is closer to 10-20 g rather than 15-40
  3. there are two pairs of arteries (i.e., 4 not two arteries)
  4. surgical damage to recurrent laryngeal nerve causes hoarseness not muteness
  5. iodination campaigns have not eliminated "cretinism" in developed countries, but have eliminated endemic iodine deficiency cretinism. Newborn screening programs have eliminated cretinism in developed countries.
Apparently there were seven inaccuracies. Where are the five other ones? Is there a list somewhere or are we expected to find them ourselves? Given that I expanded the article quite substantially a few weeks ago, this fairly low inaccuracy count is an implicit compliment :-) JFW | T@lk 12:57, 15 December 2005 (UTC)
  • I didnt see any others on a quick run through but I will go through it more carefully. I wish we knew how nitpicky the reviewer was being. The first error I listed above is a true error, though not major. The second I would call nitpicky. I wanted to ask people to list them if several of us go through this with a fine tooth comb this week to see if could find 7. Also thanks to wouterstamp for removing the copyvio text that I replaced without realizing what it was. alteripse 16:38, 15 December 2005 (UTC)

Interestingly the vandal (72.10.124.101 (talk · contribs)) was reverted every time capitalised nonsense was inserted, but his obvious copyvio was retained until WS caught it. JFW | T@lk 17:00, 15 December 2005 (UTC)

Well, strangely, that text seemed to be (re?)inserted by Alteripse: [1] (→Diseases of the thyroid gland - replacing removal by vandal) --WS 17:32, 15 December 2005 (UTC)

Nothing strange, just a mistake in thinking it had already been in the article, as I mentioned above. I am glad you caught it. alteripse 18:11, 15 December 2005 (UTC)

This is exactly why we need references. There are a ton of little factoids here which sound reasonable but I cannot easily verify. InvictaHOG 23:39, 16 December 2005 (UTC)

Just reading through, I was surprised that Vesalius missed the thyroid. And he didn't. Also sounds like it was described even before Vesalius, but I didn't have time to get to the bottom of it. InvictaHOG 04:11, 17 December 2005 (UTC)

I'll have to go over this article thoroughly with my Thyroid textbook on my lap, when I can find the time. Cybergoth 03:15, 20 December 2005 (UTC)

[edit] Errors ID'd by Nature, to correct

The results of what exactly Nature suggested should be corrected is out... italicize each bullet point once you make the correction. -- user:zanimum

  • Calcitonin production is regulated by TSH.
  • The thyroid is not enlarged during menstruation but does vary in size through the menstrual cycle.
  • C cells do not fill the spaces between follicles, they are scattered through the gland, there is also connective tissue in the intra-follicular space.
  • The description of radioactive isotopes is biased. They are very useful in the diagnosis and treatment of adult thyroid dysfunction, including cancer. The increase in thyroid cancer after Chernobyl was restricted to children.
  • Thyroid is described as ....largest endocrine gland... and quite large for an endocrine gland.. which?
  • Does not contain the information that most thyroid hormone is in the form of thyroxine and this is how it is most easily transported e.g. across the blood/brain barrier. However T3 is the biologically active form of the hormone and is produced, partly directly, but also by de-iodination of thyroxine which occurs in tissues.
  • The description of thyroid disorders should include hyperthyroidism (overactivity), hypothyroidism (under activity) and the fact that these are common affecting about 2% of the population.
It's funny that the external reviewers did not pick up all of the errors. InvictaHOG 21:44, 22 December 2005 (UTC)

[edit] Redundant paragraph

General Tojo (talk · contribs) has repeatedly reinserted a paragraph that I removed. It was originally added by an anon and contains no new information that is not already covered in the article. Unless General Tojo can offer a good reason, I really think this should stay out. JFW | T@lk 16:45, 21 June 2006 (UTC)

I don't agree at all. All articles should begin with a summary. Many people reading Wikipedia often just want a brief summary. They don't want to have to read the whole page to find what they are looking for. It's good to include a summary. --General Tojo 17:20, 21 June 2006 (UTC)

But the paragraph you keep on reinserting is not the intro. It is an extra paragraph. Do you mean the lead section should be expanded? JFW | T@lk 17:49, 21 June 2006 (UTC)

Combined and better written would be better. --General Tojo 18:21, 21 June 2006 (UTC)

Happy with the new version? JFW | T@lk 21:52, 21 June 2006 (UTC)

Structure, location, function, malfunction - it's now got all it needs to have. --General Tojo 22:06, 21 June 2006 (UTC)

[edit] Embryology

I do not know the protocol for something like this but I do believe the thyroid is from the 3rd and 4th pharyngeal pouches and therefore a developmentally abnormality results in DiGeorge's syndrome. —Preceding unsigned comment added by 05:58, 17 May 2007 (talk • contribs) 69.123.55.161

I've reverted as embryological development is from pharyngeal arches (a pharyngeal pouch is an abnormal diverticulum). David Ruben Talk 23:42, 17 May 2007 (UTC)
DiGeorge's syndrome makes interesting reading, but I'm not sure that article can be used to infer that the thyroid is from arches 3 & 4. Anyone have reliable source for its embryology ? David Ruben Talk 23:48, 17 May 2007 (UTC)

I am the poster who originally decided to switch the thyroid embyrological development to the third and fourth pharyngeal pouches. The third pharyngeal pouch forms the inferior parathyroid and the thyroid while the fourth forms the superior parathroid. I got this information from the books I am using to study for the USMLEs Step 1s. What is the correct procedure in referencing and double checking sources?



It's from the first pharyngeal pouch as it derives from the foramen caecum of the tongue and descends in the thyroglossal duct. 3+4 do give rise to the larynx/pharynx, but the thyroid is not related to these embryologically. So says my embryology textbook anyway.

[edit] TU tests needs it own article

t4 TU is indirect measure of TBG. also need info about t3 uptake

this deserves its own article. —Preceding unsigned comment added by 207.151.252.81 (talk) 21:02, 19 December 2007 (UTC)

Hi sorry don't know how to change it but thyroid ima artery is listed in the table under veins. Needs updating. —Preceding unsigned comment added by 82.11.252.72 (talk) 09:48, 7 March 2008 (UTC)