THSD1

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Thrombospondin, type I, domain containing 1
Identifiers
Symbol(s) THSD1; MGC74971; TMTSP; UNQ3010
External IDs MGI: 1929096 HomoloGene: 10264
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 55901 56229
Ensembl ENSG00000136114 ENSMUSG00000031480
Uniprot Q9NS62 Q05C26
Refseq NM_018676 (mRNA)
NP_061146 (protein)		 XM_981252 (mRNA)
XP_986346 (protein)
Location Chr 13: 51.83 - 51.88 Mb Chr 8: 23.69 - 23.73 Mb
Pubmed search [1] [2]

Thrombospondin, type I, domain containing 1, also known as THSD1, is a human gene.[1]

The protein encoded by this gene contains a type 1 thrombospondin domain, which is found in thrombospondin, a number of proteins involved in the complement pathway, as well as extracellular matrix proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.[1]

[edit] References

  1. ^ a b Entrez Gene: THSD1 thrombospondin, type I, domain containing 1.

[edit] Further reading

  • Bork P (1993). "The modular architecture of a new family of growth regulators related to connective tissue growth factor.". FEBS Lett. 327 (2): 125-30. PMID 7687569. 
  • Gruber HE, Ingram JA, Hanley EN (2007). "Immunolocalization of thrombospondin in the human and sand rat intervertebral disc.". Spine 31 (22): 2556-61. doi:10.1097/01.brs.0000241117.31510.e3. PMID 17047544. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Orr AW, Pallero MA, Xiong WC, Murphy-Ullrich JE (2005). "Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly.". J. Biol. Chem. 279 (47): 48983-92. doi:10.1074/jbc.M404881200. PMID 15371459. 
  • Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522-8. doi:10.1038/nature02379. PMID 15057823. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
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