Thrombin-activatable fibrinolysis inhibitor
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carboxypeptidase B2
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| Identifiers | |
| Symbol | CPB2 |
| Entrez | 1361 |
| HUGO | 2300 |
| OMIM | 603101 |
| RefSeq | NM_001872 |
| UniProt | Q96IY4 |
| Other data | |
| Locus | Chr. 13 q14.11 |
Thrombin-activatable fibrinolysis inhibitor (TAFI), also known as plasma carboxypeptidase B2 is a recently described plasma zymogen that, when exposed to the thrombin-thrombomodulin complex, is converted by proteolysis at Arg92 to a basic carboxypeptidase (TAFIa or activated TAFI) that inhibits fibrinolysis.
Fibrinolysis (simplified). Blue arrows denote stimulation, and red arrows inhibition.
TAFI is produced by the liver.
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