Threonine synthase

From Wikipedia, the free encyclopedia

In enzymology, a threonine synthase (EC 4.2.3.1) is an enzyme that catalyzes the chemical reaction

O-phospho-L-homoserine + H₂O L-threonine + phosphate

Thus, the two substrates of this enzyme are O-phospho-L-homoserine and H₂O, whereas its two products are L-threonine and phosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is O-phospho-L-homoserine phosphate-lyase (adding water L-threonine-forming). Other names in common use include threonine synthetase, and O-phospho-L-homoserine phospho-lyase (adding water). This enzyme participates in glycine, serine and threonine metabolism and vitamin b6 metabolism. It employs one cofactor, pyridoxal phosphate.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1UIM, 1UIN, 1V7C, 1VB3, 2C2B, 2C2G, and 2D1F.

[edit] References

• IUBMB entry for 4.2.3.1
• BRENDA references for 4.2.3.1 (Recommended.)
• PubMed references for 4.2.3.1
• PubMed Central references for 4.2.3.1
• Google Scholar references for 4.2.3.1
• FLAVIN M, SLAUGHTER C (1960). "Purification and properties of threonine synthetase of Neurospora". J. Biol. Chem. 235: 1103–8. PMID 13823379. 

[edit] External links

The CAS registry number for this enzyme class is 9023-97-6.

• IUBMB entry for 4.2.3.1

• KEGG entry for 4.2.3.1

• BRENDA entry for 4.2.3.1

• NiceZyme view of 4.2.3.1

• EC2PDB: PDB structures for 4.2.3.1

• PRIAM entry for 4.2.3.1

• PUMA2 entry for 4.2.3.1

• IntEnz: Integrated Enzyme entry for 4.2.3.1

• MetaCyc entry for 4.2.3.1

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004795: threonine synthase

• AMIGO entry for GO code 0004795: threonine synthase