THRSP

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Thyroid hormone responsive (SPOT14 homolog, rat)
Identifiers
Symbol(s) THRSP; S14; MGC21659; SPOT14
External IDs OMIM: 601926 MGI: 109126 HomoloGene: 2441
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7069 21835
Ensembl ENSG00000151365 ENSMUSG00000035686
Uniprot Q92748 Q543J4
Refseq NM_003251 (mRNA)
NP_003242 (protein)		 NM_009381 (mRNA)
NP_033407 (protein)
Location Chr 11: 77.45 - 77.46 Mb Chr 7: 97.29 - 97.29 Mb
Pubmed search [1] [2]

Thyroid hormone responsive (SPOT14 homolog, rat), also known as THRSP, is a human gene.[1]

The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism.[1]

[edit] References

  1. ^ a b Entrez Gene: THRSP thyroid hormone responsive (SPOT14 homolog, rat).

[edit] Further reading

  • Cunningham BA, Moncur JT, Huntington JT, Kinlaw WB (1998). ""Spot 14" protein: a metabolic integrator in normal and neoplastic cells.". Thyroid 8 (9): 815–25. PMID 9777755. 
  • Grillasca JP, Gastaldi M, Khiri H, et al. (1997). "Cloning and initial characterization of human and mouse Spot 14 genes.". FEBS Lett. 401 (1): 38–42. PMID 9003802. 
  • Ota Y, Mariash A, Wagner JL, Mariash CN (1997). "Cloning, expression and regulation of the human S14 gene.". Mol. Cell. Endocrinol. 126 (1): 75–81. PMID 9027365. 
  • Taviaux S, Planells R, Gastaldi M, et al. (1997). "Assignment of thyroid hormone responsive SPOT 14 homolog (THRSP) to human chromosome 11 bands q13.5-->q14.1 by in situ hybridization.". Cytogenet. Cell Genet. 76 (3-4): 219–20. PMID 9186528. 
  • Moncur JT, Park JP, Maloney M, et al. (1997). "Assignment of the "spot 14" gene (THRSP) to human chromosome band 11q13.5 by in situ hybridization.". Cytogenet. Cell Genet. 78 (2): 131–2. PMID 9371405. 
  • Cunningham BA, Maloney M, Kinlaw WB (1997). "Spot 14 protein-protein interactions: evidence for both homo- and heterodimer formation in vivo.". Endocrinology 138 (12): 5184–8. PMID 9389499. 
  • Moncur JT, Park JP, Memoli VA, et al. (1998). "The "Spot 14" gene resides on the telomeric end of the 11q13 amplicon and is expressed in lipogenic breast cancers: implications for control of tumor metabolism.". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6989–94. PMID 9618526. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Campbell MC, Anderson GW, Mariash CN (2004). "Human spot 14 glucose and thyroid hormone response: characterization and thyroid hormone response element identification.". Endocrinology 144 (12): 5242–8. doi:10.1210/en.2002-0008. PMID 12960053. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Chou WY, Cheng YS, Ho CL, et al. (2007). "Human spot 14 protein interacts physically and functionally with the thyroid receptor.". Biochem. Biophys. Res. Commun. 357 (1): 133–8. doi:10.1016/j.bbrc.2007.03.103. PMID 17418816. 
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