THOC2

From Wikipedia, the free encyclopedia

THO complex 2

Identifiers

THOC2; CXorf3; THO2; dJ506G2.1

External IDs

OMIM: 300395 MGI: 2442413 HomoloGene: 69669

Gene ontology
Molecular Function:	• RNA binding
Cellular Component:	• nucleus
Biological Process:	• mRNA processing • transport • RNA splicing • mRNA transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001081550 (mRNA)
NP_001075019 (protein)

XM_284697 (mRNA)
XP_284697 (protein)

Location

Chr X: 122.57 - 122.69 Mb

Chr X: 38.04 - 38.16 Mb

Pubmed search

[1]

[2]

THO complex 2, also known as THOC2, is a human gene.^[1]

THO2 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), HPR1 (MIM 606930), ALY (MIM 604171), and UAP56 (MIM 606390).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: THOC2 THO complex 2.

[edit] Further reading

Coffey AJ, Brooksbank RA, Brandau O, et al. (1998). "Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene.". Nat. Genet. 20 (2): 129-35. doi:10.1038/2424. PMID 9771704.
Strässer K, Masuda S, Mason P, et al. (2002). "TREX is a conserved complex coupling transcription with messenger RNA export.". Nature 417 (6886): 304-8. doi:10.1038/417304a. PMID 11979277.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Masuda S, Das R, Cheng H, et al. (2005). "Recruitment of the human TREX complex to mRNA during splicing.". Genes Dev. 19 (13): 1512-7. doi:10.1101/gad.1302205. PMID 15998806.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285-92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.