Thiosulfate-thiol sulfurtransferase

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In enzymology, a thiosulfate-thiol sulfurtransferase (EC 2.8.1.3) is an enzyme that catalyzes the chemical reaction

thiosulfate + 2 glutathione $\rightleftharpoons$ sulfite + glutathione disulfide + sulfide

Thus, the two substrates of this enzyme are thiosulfate and glutathione, whereas its 3 products are sulfite, glutathione disulfide, and sulfide.

This enzyme belongs to the family of transferases, specifically the sulfurtransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is thiosulfate:thiol sulfurtransferase. Other names in common use include glutathione-dependent thiosulfate reductase, sulfane reductase, and sulfane sulfurtransferase. This enzyme participates in glutathione metabolism.

[edit] References

IUBMB entry for 2.8.1.3
BRENDA references for 2.8.1.3 (Recommended.)
PubMed references for 2.8.1.3
PubMed Central references for 2.8.1.3
Google Scholar references for 2.8.1.3
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Sido B and Koj A (1972). "Separation of rhodanese and thiosulfate reductase activities in carp liver extracts". Acta Biol. Cracow Ser. Zoo. 15: 97–103.
Uhteg LC, Westley J (1979). "Purification and steady-state kinetic analysis of yeast thiosulfate reductase". Arch. Biochem. Biophys. 195: 211–22. PMID 383018.