Thiophosphate

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A thiophosphate is a chemical structure containing phosphorus bonded to one or more sulfur atoms and zero or more oxygen atoms; the name is used to refer to both the PS4 group and the PO3S group.

A number of insecticides, such as diazinon, have thiophosphate groups.

Thiophosphate (PS4) is occasionally used as a ligand with zinc in inorganic chemistry;[1] it is used as a competitive inhibitor for phosphate in studying ATP binding, and nucleic acid with some of the phosphate groups replaced with thiophosphate (PO3S) is sometimes synthesised as part of a substitution interference assay to determine which phosphate groups are important for formation of the correct function of a ribozyme. Thiophosphate-substituted nucleic acid is also used in experiments to determine how transcriptase reacts to oddities in its input nucleic acid sequence.[2]

[edit] References

  1. ^ Poat JC et al (1990). "A thiophosphate bridged platinum–zinc hetero-bimetallic complex: [(Me2PhP)2Pt{OSP(OR)2}2ZnCl2". J Chem Soc Chem Commun: 1036–1038. 
  2. ^ Lorsch JR, Bartel DP, Szostak JW. (1995). "Reverse transcriptase reads through a 2'–5' linkage and a 2'-thiphosphate in a template". Nucleic Acids Res 23: 2811–2814.