Thiomorpholine-carboxylate dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a thiomorpholine-carboxylate dehydrogenase (EC 1.5.1.25) is an enzyme that catalyzes the chemical reaction

thiomorpholine 3-carboxylate + NAD(P)+ 3,4-dehydro-thiomorpholine-3-carboxylate + NAD(P)H + H⁺

The 3 substrates of this enzyme are thiomorpholine 3-carboxylate, NAD⁺, and NADP⁺, whereas its 4 products are 3,4-dehydro-thiomorpholine-3-carboxylate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is thiomorpholine-3-carboxylate:NAD(P)+ 5,6-oxidoreductase. Other names in common use include ketimine reductase, and ketimine-reducing enzyme.

[edit] References

• IUBMB entry for 1.5.1.25
• BRENDA references for 1.5.1.25 (Recommended.)
• PubMed references for 1.5.1.25
• PubMed Central references for 1.5.1.25
• Google Scholar references for 1.5.1.25
• Nardini M, Ricci G, Caccuri AM, Solinas SP, Vesci L, Cavallini D (1988). "Purification and characterization of a ketimine-reducing enzyme". Eur. J. Biochem. 173: 689–94. doi:10.1111/j.1432-1033.1988.tb14053.x. PMID 3371353. 

[edit] External links

The CAS registry number for this enzyme class is 115232-54-7.

• IUBMB entry for 1.5.1.25

• KEGG entry for 1.5.1.25

• BRENDA entry for 1.5.1.25

• NiceZyme view of 1.5.1.25

• EC2PDB: PDB structures for 1.5.1.25

• PRIAM entry for 1.5.1.25

• PUMA2 entry for 1.5.1.25

• IntEnz: Integrated Enzyme entry for 1.5.1.25

• MetaCyc entry for 1.5.1.25

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047127: thiomorpholine-carboxylate dehydrogenase

• AMIGO entry for GO code 0047127: thiomorpholine-carboxylate dehydrogenase