Thiocyanate hydrolase

From Wikipedia, the free encyclopedia

In enzymology, a thiocyanate hydrolase (EC 3.5.5.8) is an enzyme that catalyzes the chemical reaction

thiocyanate + 2 H₂O $\rightleftharpoons$ carbonyl sulfide + NH₃ + HO-

Thus, the two substrates of this enzyme are thiocyanate and H₂O, whereas its 3 products are carbonyl sulfide, NH₃, and HO-.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in nitriles. The systematic name of this enzyme class is thiocyanate aminohydrolase.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 2DD4, 2DD5, 2DXB, and 2DXC.

[edit] References

IUBMB entry for 3.5.5.8
BRENDA references for 3.5.5.8 (Recommended.)
PubMed references for 3.5.5.8
PubMed Central references for 3.5.5.8
Google Scholar references for 3.5.5.8
Katayama Y, Matsushita Y, Kaneko M, Kondo M, Mizuno T, Nyunoya H (1998). "Cloning of genes coding for the three subunits of thiocyanate hydrolase of Thiobacillus thioparus THI 115 and their evolutionary relationships to nitrile hydratase". J. Bacteriol. 180: 2583–9. PMID 9573140.
Katayama Y, Narahara Y, Inoue Y, Amano F, Kanagawa T, Kuraishi H (1992). "A thiocyanate hydrolase of Thiobacillus thioparus. A novel enzyme catalyzing the formation of carbonyl sulfide from thiocyanate". J. Biol. Chem. 267: 9170–5. PMID 1577754.