Thiazepines

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Diltiazem. Thiazepine is the seven membered ring in the middle.
Diltiazem. Thiazepine is the seven membered ring in the middle.

Thiazepines are a substituted thiepins, with a nitrogen replacing a carbon in the seven-membered heterocyclic compound.

Benzothiapines (such as diltiazem) have a single benzene attached to the ring, while dibenzothiazepines have two.

  • Diltiazem, a benzothiazepine, is intermediate in properties between verapamil and the dihydropyridines.
  • Diltiazem is used to treat variant (Prinzmetal's) angina, either naturally occurring or drug-induced and stable angina.

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