Thiamphenicol
From Wikipedia, the free encyclopedia
Thiamphenicol
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Systematic (IUPAC) name | |
2,2-dichloro-N-[(1R,2R)- 1,3-dihydroxy-1- (4-methylsulfonylphenyl) propan-2-yl] acetamide | |
Identifiers | |
CAS number | |
ATC code | J01 |
PubChem | |
DrugBank | |
Chemical data | |
Formula | C12H15Cl2NO5S |
Mol. mass | 356.223 g/mol |
Pharmacokinetic data | |
Bioavailability | ? |
Metabolism | hepatic |
Half life | 5.0 hours |
Excretion | renal |
Therapeutic considerations | |
Pregnancy cat. |
? |
Legal status |
none |
Routes | IV, IM, O |
Thiamphenicol is an antibiotic. It is the methyl-sulfonyl analogue of chloramphenicol and has a similar spectrum of activity, but is 2.5 to 5 times as potent. Like chloramphenicol, is insoluble in water but highly soluble in lipids. It is used in many countries as a veterinary antibiotic, but is available in China and Italy for use in humans. Its main advantage over chloramphenicol is that it has never been associated with aplastic anaemia.
[edit] Alternative names
- Dextrosulphenidol
- Thiophenicol
[edit] External links
- Overview at World Health Organization - Food and Agriculture Organization
- Raymond J, Boutros N, Bergeret M (2004). "Role of thiamphenicol in the treatment of community-acquired lung infections". Med Trop (Mars) 64 (1): 33–8. PMID 15224555.
- Marchese A, Debbia E, Tonoli E, Gualco L, Schito A (2002). "In vitro activity of thiamphenicol against multiresistant Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in Italy.". J Chemother 14 (6): 554–61. PMID 12583545.
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