Thiamphenicol

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Thiamphenicol
Systematic (IUPAC) name
2,2-dichloro-N-[(1R,2R)- 1,3-dihydroxy-1- (4-methylsulfonylphenyl) propan-2-yl] acetamide
Identifiers
CAS number 15318-45-3
ATC code J01BA02
PubChem 27200
DrugBank ?
Chemical data
Formula C12H15Cl2NO5S 
Mol. mass 356.223 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism hepatic
Half life 5.0 hours
Excretion renal
Therapeutic considerations
Pregnancy cat.

?

Legal status

none

Routes IV, IM, O

Thiamphenicol is an antibiotic. It is the methyl-sulfonyl analogue of chloramphenicol and has a similar spectrum of activity, but is 2.5 to 5 times as potent. Like chloramphenicol, is insoluble in water but highly soluble in lipids. It is used in many countries as a veterinary antibiotic, but is available in China and Italy for use in humans. Its main advantage over chloramphenicol is that it has never been associated with aplastic anaemia.

[edit] Alternative names

  • Dextrosulphenidol
  • Thiophenicol

[edit] External links

  • Overview at World Health Organization - Food and Agriculture Organization
  • Raymond J, Boutros N, Bergeret M (2004). "Role of thiamphenicol in the treatment of community-acquired lung infections". Med Trop (Mars) 64 (1): 33–8. PMID 15224555. 
  • Marchese A, Debbia E, Tonoli E, Gualco L, Schito A (2002). "In vitro activity of thiamphenicol against multiresistant Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in Italy.". J Chemother 14 (6): 554–61. PMID 12583545.