THBS4

From Wikipedia, the free encyclopedia

Thrombospondin 4

Identifiers

External IDs

OMIM: 600715 MGI: 1101779 HomoloGene: 20691

Gene ontology
Molecular Function:	• structural molecule activity • calcium ion binding • protein binding • heparin binding
Cellular Component:	• extracellular region • proteinaceous extracellular matrix
Biological Process:	• substrate-bound cell migration, cell extension • cell adhesion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003248 (mRNA)
NP_003239 (protein)

NM_011582 (mRNA)
NP_035712 (protein)

Location

Chr 5: 79.37 - 79.41 Mb

Chr 13: 93.85 - 93.9 Mb

Pubmed search

[1]

[2]

Thrombospondin 4, also known as THBS4, is a human gene.^[1]

The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. Studies of the rat counterpart suggest that this protein may be involved in local signaling in the developing and adult nervous system.^[1]

[edit] References

^ ^a ^b Entrez Gene: THBS4 thrombospondin 4.

[edit] Further reading

Arber S, Caroni P (1996). "Thrombospondin-4, an extracellular matrix protein expressed in the developing and adult nervous system promotes neurite outgrowth.". J. Cell Biol. 131 (4): 1083-94. PMID 7490284.
Lawler J, McHenry K, Duquette M, Derick L (1995). "Characterization of human thrombospondin-4.". J. Biol. Chem. 270 (6): 2809-14. PMID 7852353.
Lawler J, Duquette M, Urry L, et al. (1993). "The evolution of the thrombospondin gene family.". J. Mol. Evol. 36 (6): 509-16. PMID 8350346.
Lawler J, Duquette M, Whittaker CA, et al. (1993). "Identification and characterization of thrombospondin-4, a new member of the thrombospondin gene family.". J. Cell Biol. 120 (4): 1059-67. PMID 8432726.
Newton G, Weremowicz S, Morton CC, et al. (2000). "The thrombospondin-4 gene.". Mamm. Genome 10 (10): 1010-6. PMID 10501972.
Carron JA, Hiscott P, Hagan S, et al. (2001). "Cultured human retinal pigment epithelial cells differentially express thrombospondin-1, -2, -3, and -4.". Int. J. Biochem. Cell Biol. 32 (11-12): 1137-42. PMID 11137453.
Luo J, Dunn T, Ewing C, et al. (2002). "Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis.". Prostate 51 (3): 189-200. doi:10.1002/pros.10087. PMID 11967953.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Congote LF, Difalco MR, Gibbs BF (2004). "The C-terminal peptide of thrombospondin-4 stimulates erythroid cell proliferation.". Biochem. Biophys. Res. Commun. 324 (2): 673-8. doi:10.1016/j.bbrc.2004.09.107. PMID 15474480.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
van Doorn R, Zoutman WH, Dijkman R, et al. (2005). "Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73.". J. Clin. Oncol. 23 (17): 3886-96. doi:10.1200/JCO.2005.11.353. PMID 15897551.
Stenina OI, Ustinov V, Krukovets I, et al. (2006). "Polymorphisms A387P in thrombospondin-4 and N700S in thrombospondin-1 perturb calcium binding sites.". FASEB J. 19 (13): 1893-5. doi:10.1096/fj.05-3712fje. PMID 16148025.
Misenheimer TM, Mosher DF (2006). "Biophysical characterization of the signature domains of thrombospondin-4 and thrombospondin-2.". J. Biol. Chem. 280 (50): 41229-35. doi:10.1074/jbc.M504696200. PMID 16246837.
Cui J, Randell E, Renouf J, et al. (2006). "Thrombospondin-4 1186G>C (A387P) is a sex-dependent risk factor for myocardial infarction: a large replication study with increased sample size from the same population.". Am. Heart J. 152 (3): 543.e1-5. doi:10.1016/j.ahj.2006.06.002. PMID 16923428.
Cáceres M, Suwyn C, Maddox M, et al. (2007). "Increased cortical expression of two synaptogenic thrombospondins in human brain evolution.". Cereb. Cortex 17 (10): 2312-21. doi:10.1093/cercor/bhl140. PMID 17182969.