THBS3

From Wikipedia, the free encyclopedia

Thrombospondin 3

Identifiers

THBS3; MGC119564; MGC119565; TSP3

External IDs

OMIM: 188062 MGI: 98739 HomoloGene: 5159

Gene ontology
Molecular Function:	• structural molecule activity • calcium ion binding • protein binding • heparin binding
Cellular Component:	• extracellular region • proteinaceous extracellular matrix
Biological Process:	• cell motility • cell adhesion • cell-matrix adhesion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007112 (mRNA)
NP_009043 (protein)

NM_013691 (mRNA)
NP_038719 (protein)

Location

Chr 1: 153.43 - 153.44 Mb

Chr 3: 89.3 - 89.31 Mb

Pubmed search

[1]

[2]

Thrombospondin 3, also known as THBS3, is a human gene.^[1]

The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1.^[1]

[edit] References

^ ^a ^b Entrez Gene: THBS3 thrombospondin 3.

[edit] Further reading

O'Rourke KM, Laherty CD, Dixit VM (1993). "Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers.". J. Biol. Chem. 267 (35): 24921–4. PMID 1459996.
Vos HL, Devarayalu S, de Vries Y, Bornstein P (1992). "Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family.". J. Biol. Chem. 267 (17): 12192–6. PMID 1601886.
Adolph KW, Long GL, Winfield S, et al. (1995). "Structure and organization of the human thrombospondin 3 gene (THBS3).". Genomics 27 (2): 329–36. doi:10.1006/geno.1995.1050. PMID 7558000.
Qabar A, Derick L, Lawler J, Dixit V (1995). "Thrombospondin 3 is a pentameric molecule held together by interchain disulfide linkage involving two cysteine residues.". J. Biol. Chem. 270 (21): 12725–9. PMID 7759526.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Qabar AN, Lin Z, Wolf FW, et al. (1994). "Thrombospondin 3 is a developmentally regulated heparin binding protein.". J. Biol. Chem. 269 (2): 1262–9. PMID 8288588.
Bornstein P, Devarayalu S, Edelhoff S, Disteche CM (1993). "Isolation and characterization of the mouse thrombospondin 3 (Thbs3) gene.". Genomics 15 (3): 607–13. doi:10.1006/geno.1993.1114. PMID 8468055.
Winfield SL, Tayebi N, Martin BM, et al. (1997). "Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease.". Genome Res. 7 (10): 1020–6. PMID 9331372.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Adolph KW (1999). "Relative abundance of thrombospondin 2 and thrombospondin 3 mRNAs in human tissues.". Biochem. Biophys. Res. Commun. 258 (3): 792–6. doi:10.1006/bbrc.1999.0710. PMID 10329465.
Adolph KW, Bornstein P (2000). "The human thrombospondin 3 gene: analysis of transcription initiation and an alternatively spliced transcript.". Mol. Cell Biol. Res. Commun. 2 (1): 47–52. doi:10.1006/mcbr.1999.0148. PMID 10527891.
Carron JA, Hiscott P, Hagan S, et al. (2001). "Cultured human retinal pigment epithelial cells differentially express thrombospondin-1, -2, -3, and -4.". Int. J. Biochem. Cell Biol. 32 (11-12): 1137–42. PMID 11137453.
Armstrong DJ, Hiscott P, Batterbury M, Kaye S (2002). "Corneal stromal cells (keratocytes) express thrombospondins 2 and 3 in wound repair phenotype.". Int. J. Biochem. Cell Biol. 34 (6): 588–93. PMID 11943589.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Dalla-Torre CA, Yoshimoto M, Lee CH, et al. (2006). "Effects of THBS3, SPARC and SPP1 expression on biological behavior and survival in patients with osteosarcoma.". BMC Cancer 6: 237. doi:10.1186/1471-2407-6-237. PMID 17022822.