THAP1

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THAP domain containing, apoptosis associated protein 1
Identifiers
Symbol(s) THAP1; FLJ10477; MGC33014
External IDs OMIM: 609520 MGI: 1921004 HomoloGene: 10005
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 55145 73754
Ensembl ENSG00000131931 ENSMUSG00000037214
Uniprot Q9NVV9 Q8CHW1
Refseq NM_018105 (mRNA)
NP_060575 (protein)		 NM_199042 (mRNA)
NP_950243 (protein)
Location Chr 8: 42.81 - 42.82 Mb Chr 8: 27.62 - 27.63 Mb
Pubmed search [1] [2]

THAP domain containing, apoptosis associated protein 1, also known as THAP1, is a human gene.[1]

The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed.[1]

[edit] References

  1. ^ a b Entrez Gene: THAP1 THAP domain containing, apoptosis associated protein 1.

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Roussigne M, Kossida S, Lavigne AC, et al. (2003). "The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase.". Trends Biochem. Sci. 28 (2): 66-9. PMID 12575992. 
  • Roussigne M, Cayrol C, Clouaire T, et al. (2003). "THAP1 is a nuclear proapoptotic factor that links prostate-apoptosis-response-4 (Par-4) to PML nuclear bodies.". Oncogene 22 (16): 2432-42. doi:10.1038/sj.onc.1206271. PMID 12717420. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Clouaire T, Roussigne M, Ecochard V, et al. (2005). "The THAP domain of THAP1 is a large C2CH module with zinc-dependent sequence-specific DNA-binding activity.". Proc. Natl. Acad. Sci. U.S.A. 102 (19): 6907-12. doi:10.1073/pnas.0406882102. PMID 15863623. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801-14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
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