TGM4

From Wikipedia, the free encyclopedia

Transglutaminase 4 (prostate)

Identifiers

TGM4; TGP; hTGP

External IDs

OMIM: 600585 MGI: 3027002 HomoloGene: 20689

Gene ontology
Molecular Function:	• protein-glutamine gamma-glutamyltransferase activity • calcium ion binding • acyltransferase activity • transferase activity
Cellular Component:	• cellular_component
Biological Process:	• peptide cross-linking • protein amino acid polyamination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_003241 (mRNA)
NP_003232 (protein)

XM_989083 (mRNA)
XP_994177 (protein)

Location

Chr 3: 44.89 - 44.93 Mb

Chr 9: 122.88 - 122.92 Mb

Pubmed search

[1]

[2]

Transglutaminase 4 (prostate), also known as TGM4, is a human gene.^[1]

[edit] References

^ Entrez Gene: TGM4 transglutaminase 4 (prostate).

[edit] Further reading

Davies G, Ablin RJ, Mason MD, Jiang WG (2007). "Expression of the prostate transglutaminase (TGase-4) in prostate cancer cells and its impact on the invasiveness of prostate cancer.". J. Exp. Ther. Oncol. 6 (3): 257-64. PMID 17552366.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Dubbink HJ, de Waal L, van Haperen R, et al. (1998). "The human prostate-specific transglutaminase gene (TGM4): genomic organization, tissue-specific expression, and promoter characterization.". Genomics 51 (3): 434-44. doi:10.1006/geno.1998.5393. PMID 9721214.
Dubbink HJ, Verkaik NS, Faber PW, et al. (1996). "Tissue specific and androgen-regulated expression of human prostate-specific transglutaminase.". Biochem. J. 315 ( Pt 3): 901-8. PMID 8645175.
Grant FJ, Taylor DA, Sheppard PO, et al. (1994). "Molecular cloning and characterization of a novel transglutaminase cDNA from a human prostate cDNA library.". Biochem. Biophys. Res. Commun. 203 (2): 1117-23. PMID 7916568.
Amendola A, Lombardi G, Oliverio S, et al. (1994). "HIV-1 gp120-dependent induction of apoptosis in antigen-specific human T cell clones is characterized by 'tissue' transglutaminase expression and prevented by cyclosporin A.". FEBS Lett. 339 (3): 258-64. PMID 7906657.
Mariniello L, Esposito C, Di Pierro P, et al. (1993). "Human-immunodeficiency-virus transmembrane glycoprotein gp41 is an amino acceptor and donor substrate for transglutaminase in vitro.". Eur. J. Biochem. 215 (1): 99-104. PMID 7688299.
Gentile V, Grant FJ, Porta R, Baldini A (1995). "Localization of the human prostate transglutaminase (type IV) gene (TGM4) to chromosome 3p21.33-p22 by fluorescence in situ hybridization.". Genomics 27 (1): 219-20. doi:10.1006/geno.1995.1032. PMID 7665178.