TGF beta receptor 1

From Wikipedia, the free encyclopedia

Transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)

PDB rendering based on 1b6c.

Available structures: 1b6c, 1ias, 1py5, 1rw8, 1vjy

Identifiers

Symbol(s)

TGFBR1; ACVRLK4; AAT5; ALK-5; ALK5; SKR4; TGFR-1

External IDs

OMIM: 190181 MGI: 98728 HomoloGene: 3177

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • receptor activity • transforming growth factor beta receptor activity, type I • ATP binding • transferase activity • manganese ion binding • SMAD binding • transforming growth factor beta binding
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• in utero embryonic development • protein amino acid phosphorylation • signal transduction • transforming growth factor beta receptor complex assembly • positive regulation of cell proliferation • germ cell migration • embryonic development • collagen fibril organization • regulation of transcription • neuron fate commitment

Orthologs

Human

Mouse

Refseq

NM_004612 (mRNA)
NP_004603 (protein)

NM_009370 (mRNA)
NP_033396 (protein)

Location

Chr 9: 100.91 - 100.96 Mb

Chr 4: 47.37 - 47.44 Mb

Pubmed search

[1]

[2]

Transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) is a TGF beta receptor. TGFBR1 is its human gene.

The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).^[1]

[edit] See also

TGF beta receptors

[edit] References

^ Entrez Gene: TGFBR1 transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa).

[edit] Further reading

Massagué J (1992). "Receptors for the TGF-beta family.". Cell 69 (7): 1067–70. PMID 1319842.
Wrana JL (1998). "TGF-beta receptors and signalling mechanisms.". Mineral and electrolyte metabolism 24 (2-3): 120–30. PMID 9525694.
Josso N, di Clemente N, Gouédard L (2001). "Anti-Müllerian hormone and its receptors.". Mol. Cell. Endocrinol. 179 (1-2): 25–32. PMID 11420127.

v • d • e Transmembrane receptors: immune receptors

Cytokine receptor	Type I: Interleukins (2, 3, 4, 5, 6, 7, 9, 11, 12, 13, 15, 21, 23, 27), CSF receptors (EPO, GM-CSF, G-CSF), GH, prolactin, Oncostatin M,Leukemia inhibitory factor - common subunits (Common gamma chain, common beta chain, CSF2RB) Type II: Interleukins (10, 20, 22, 28) - interferon (-α/β, -γ) immunoglobulin superfamily: CSF1, C-kit, IL-1, IL-18 Tumor necrosis factor: CD27, CD30, CD40, CD120, Lymphotoxin β Chemokines: IL-8 (α, β), CCR1,CXCR4 Other: IL-17, TGF-beta (1, 2)

Pattern recognition/Toll-like	TLR 1 - TLR 2 - TLR 3 - TLR 4 - TLR 5 - TLR 6 - TLR 7 - TLR 8 - TLR 9 - TLR 10

Fc receptor	ε (FcεRI, FcεRII) - γ (FcγRI, FcγRII, FcγRIII) - α/μ (FcαRI, Fcα/μR) - Neonatal

Lymphocyte homing receptor	CD44 - L-selectin - VLA-4 - LFA-1

other	Antigen receptor (B-cell, T cell) - Complement - Formyl peptide - Immunophilins - Integrin - Killer-cell immunoglobulin-like - Scavenger