TFPI2

From Wikipedia, the free encyclopedia

Tissue factor pathway inhibitor 2

PDB rendering based on 1zr0.

Available structures: 1zr0

Identifiers

Symbol(s)

TFPI2; PP5; FLJ21164; TFPI-2

External IDs

OMIM: 600033 MGI: 108543 HomoloGene: 38194

Gene ontology
Molecular Function:	• serine-type endopeptidase inhibitor activity • extracellular matrix structural constituent
Cellular Component:	• extracellular region • proteinaceous extracellular matrix
Biological Process:	• blood coagulation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006528 (mRNA)
NP_006519 (protein)

NM_009364 (mRNA)
NP_033390 (protein)

Location

Chr 7: 93.35 - 93.36 Mb

Chr 6: 3.91 - 3.92 Mb

Pubmed search

[1]

[2]

Tissue factor pathway inhibitor 2, also known as TFPI2, is a human gene.^[1]

[edit] References

^ Entrez Gene: TFPI2 tissue factor pathway inhibitor 2.

[edit] Further reading

Bützow R, Huhtala ML, Bohn H, et al. (1988). "Purification and characterization of placental protein 5.". Biochem. Biophys. Res. Commun. 150 (1): 483–90. PMID 3276312.
Takayama M, Soma H, Saito T, et al. (1983). "Circulating levels of placental protein 5 in normal and abnormal pregnancies.". Gynecol. Obstet. Invest. 16 (1): 13–26. PMID 6884838.
Miyagi Y, Koshikawa N, Yasumitsu H, et al. (1995). "cDNA cloning and mRNA expression of a serine proteinase inhibitor secreted by cancer cells: identification as placental protein 5 and tissue factor pathway inhibitor-2.". J. Biochem. 116 (5): 939–42. PMID 7896752.
Sprecher CA, Kisiel W, Mathewes S, Foster DC (1994). "Molecular cloning, expression, and partial characterization of a second human tissue-factor-pathway inhibitor.". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3353–7. PMID 8159751.
Petersen LC, Sprecher CA, Foster DC, et al. (1996). "Inhibitory properties of a novel human Kunitz-type protease inhibitor homologous to tissue factor pathway inhibitor.". Biochemistry 35 (1): 266–72. doi:10.1021/bi951501d. PMID 8555184.
Miyagi Y, Yasumitsu H, Eki T, et al. (1996). "Assignment of the human PP5/TFPI-2 gene to 7q22 by FISH and PCR-based human/rodent cell hybrid mapping panel analysis.". Genomics 35 (1): 267–8. doi:10.1006/geno.1996.0353. PMID 8661135.
Rao CN, Reddy P, Liu Y, et al. (1996). "Extracellular matrix-associated serine protease inhibitors (Mr 33,000, 31,000, and 27,000) are single-gene products with differential glycosylation: cDNA cloning of the 33-kDa inhibitor reveals its identity to tissue factor pathway inhibitor-2.". Arch. Biochem. Biophys. 335 (1): 82–92. doi:10.1006/abbi.1996.0484. PMID 8914837.
Miyagi Y, Yasumitsu H, Mizushima H, et al. (1997). "Cloning of the cDNA encoding mouse PP5/TFPI-2 and mapping of the gene to chromosome 6.". DNA Cell Biol. 15 (11): 947–54. PMID 8945635.
Iino M, Foster DC, Kisiel W (1998). "Quantification and characterization of human endothelial cell-derived tissue factor pathway inhibitor-2.". Arterioscler. Thromb. Vasc. Biol. 18 (1): 40–6. PMID 9445254.
Udagawa K, Miyagi Y, Hirahara F, et al. (1998). "Specific expression of PP5/TFPI2 mRNA by syncytiotrophoblasts in human placenta as revealed by in situ hybridization.". Placenta 19 (2-3): 217–23. PMID 9548189.
Shinoda E, Yui Y, Hattori R, et al. (1999). "Tissue factor pathway inhibitor-2 is a novel mitogen for vascular smooth muscle cells.". J. Biol. Chem. 274 (9): 5379–84. PMID 10026147.
Liu Y, Stack SM, Lakka SS, et al. (1999). "Matrix localization of tissue factor pathway inhibitor-2/matrix-associated serine protease inhibitor (TFPI-2/MSPI) involves arginine-mediated ionic interactions with heparin and dermatan sulfate: heparin accelerates the activity of TFPI-2/MSPI toward plasmin.". Arch. Biochem. Biophys. 370 (1): 112–8. doi:10.1006/abbi.1999.1371. PMID 10496984.
Kamei S, Kazama Y, Kuijper JL, et al. (2001). "Genomic structure and promoter activity of the human tissue factor pathway inhibitor-2 gene.". Biochim. Biophys. Acta 1517 (3): 430–5. PMID 11342222.
Crawley JT, Goulding DA, Ferreira V, et al. (2002). "Expression and localization of tissue factor pathway inhibitor-2 in normal and atherosclerotic human vessels.". Arterioscler. Thromb. Vasc. Biol. 22 (2): 218–24. PMID 11834519.
Konduri SD, Osman FA, Rao CN, et al. (2002). "Minimal and inducible regulation of tissue factor pathway inhibitor-2 in human gliomas.". Oncogene 21 (6): 921–8. doi:10.1038/sj.onc.1204983. PMID 11840337.
Udagawa K, Yasumitsu H, Esaki M, et al. (2002). "Subcellular localization of PP5/TFPI-2 in human placenta: a possible role of PP5/TFPI-2 as an anti-coagulant on the surface of syncytiotrophoblasts.". Placenta 23 (2-3): 145–53. doi:10.1053/plac.2001.0774. PMID 11945080.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hubé F, Reverdiau P, Iochmann S, et al. (2003). "Demonstration of a tissue factor pathway inhibitor 2 messenger RNA synthesis by pure villous cytotrophoblast cells isolated from term human placentas.". Biol. Reprod. 68 (5): 1888–94. doi:10.1095/biolreprod.102.011858. PMID 12606321.
Rao CN, Segawa T, Navari JR, et al. (2003). "Methylation of TFPI-2 gene is not the sole cause of its silencing.". Int. J. Oncol. 22 (4): 843–8. PMID 12632077.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.