TFG (gene)

From Wikipedia, the free encyclopedia

TRK-fused gene

Identifiers

TFG; FLJ36137; TF6; TRKT3

External IDs

OMIM: 602498 MGI: 1338041 HomoloGene: 4426

Gene ontology
Molecular Function:	• transmembrane receptor protein tyrosine kinase activity • signal transducer activity • ATP binding • identical protein binding
Cellular Component:	• cytoplasm • membrane
Biological Process:	• protein amino acid phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of I-kappaB kinase/NF-kappaB cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001007565 (mRNA)
NP_001007566 (protein)

NM_019678 (mRNA)
NP_062652 (protein)

Location

Chr 3: 101.91 - 101.95 Mb

Chr 16: 56.62 - 56.64 Mb

Pubmed search

[1]

[2]

TRK-fused gene, also known as TFG, is a human gene.^[1]

[edit] References

^ Entrez Gene: TFG TRK-fused gene.

[edit] Further reading

Sasaoka T, Kobayashi M (2000). "The functional significance of Shc in insulin signaling as a substrate of the insulin receptor.". Endocr. J. 47 (4): 373–81. PMID 11075717.
Greco A, Mariani C, Miranda C, et al. (1995). "The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain.". Mol. Cell. Biol. 15 (11): 6118–27. PMID 7565764.
Gotoh N, Toyoda M, Shibuya M (1997). "Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation.". Mol. Cell. Biol. 17 (4): 1824–31. PMID 9121430.
Mencinger M, Panagopoulos I, Andreasson P, et al. (1997). "Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma.". Genomics 41 (3): 327–31. doi:10.1006/geno.1997.4625. PMID 9169129.
Soltoff SP, Avraham H, Avraham S, Cantley LC (1998). "Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C.". J. Biol. Chem. 273 (5): 2653–60. PMID 9446569.
Walk SF, March ME, Ravichandran KS (1998). "Roles of Lck, Syk and ZAP-70 tyrosine kinases in TCR-mediated phosphorylation of the adapter protein Shc.". Eur. J. Immunol. 28 (8): 2265–75. PMID 9710204.
Wary KK, Mariotti A, Zurzolo C, Giancotti FG (1998). "A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth.". Cell 94 (5): 625–34. PMID 9741627.
Marchetto S, Fournier E, Beslu N, et al. (1999). "SHC and SHIP phosphorylation and interaction in response to activation of the FLT3 receptor.". Leukemia 13 (9): 1374–82. PMID 10482988.
Hernández L, Pinyol M, Hernández S, et al. (1999). "TRK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally different TFG-ALK translocations.". Blood 94 (9): 3265–8. PMID 10556217.
Nakajima K, Yamauchi K, Shigematsu S, et al. (2000). "Selective attenuation of metabolic branch of insulin receptor down-signaling by high glucose in a hepatoma cell line, HepG2 cells.". J. Biol. Chem. 275 (27): 20880–6. doi:10.1074/jbc.M905410199. PMID 10764799.
Slack BE (2000). "The m3 muscarinic acetylcholine receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase.". Biochem. J. 348 Pt 2: 381–7. PMID 10816433.
Schaak S, Cussac D, Cayla C, et al. (2000). "Alpha(2) adrenoceptors regulate proliferation of human intestinal epithelial cells.". Gut 47 (2): 242–50. PMID 10896916.
Imokawa G, Kobayasi T, Miyagishi M (2000). "Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes. Cross-talk via trans-activation of the tyrosine kinase c-kit receptor.". J. Biol. Chem. 275 (43): 33321–8. doi:10.1074/jbc.M004346200. PMID 10921922.
Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMID 11591653.
Hernández L, Beà S, Bellosillo B, et al. (2002). "Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity.". Am. J. Pathol. 160 (4): 1487–94. PMID 11943732.
Roccato E, Miranda C, Ranzi V, et al. (2002). "Biological activity of the thyroid TRK-T3 oncogene requires signalling through Shc.". Br. J. Cancer 87 (6): 645–53. doi:10.1038/sj.bjc.6600544. PMID 12237775.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.