TFEB

From Wikipedia, the free encyclopedia

Transcription factor EB

Identifiers

TFEB; AlphaTFEB; TCFEB

External IDs

OMIM: 600744 MGI: 103270 HomoloGene: 5182

Gene ontology
Molecular Function:	• transcription factor activity • transcription regulator activity
Cellular Component:	• nucleus • transcription factor complex
Biological Process:	• regulation of transcription • positive regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007162 (mRNA)
NP_009093 (protein)

NM_011549 (mRNA)
NP_035679 (protein)

Location

Chr 6: 41.76 - 41.81 Mb

Chr 17: 47.2 - 47.26 Mb

Pubmed search

[1]

[2]

Transcription factor EB, also known as TFEB, is a human gene.^[1]

[edit] References

^ Entrez Gene: TFEB transcription factor EB.

[edit] Further reading

Carr CS, Sharp PA (1990). "A helix-loop-helix protein related to the immunoglobulin E box-binding proteins.". Mol. Cell. Biol. 10 (8): 4384–8. PMID 2115126.
Steingrímsson E, Sawadogo M, Gilbert DJ, et al. (1996). "Murine chromosomal location of five bHLH-Zip transcription factor genes.". Genomics 28 (2): 179–83. doi:10.1006/geno.1995.1129. PMID 8530024.
Steingrímsson E, Tessarollo L, Reid SW, et al. (1999). "The bHLH-Zip transcription factor Tfeb is essential for placental vascularization.". Development 125 (23): 4607–16. PMID 9806910.
Verastegui C, Bertolotto C, Bille K, et al. (2000). "TFE3, a transcription factor homologous to microphthalmia, is a potential transcriptional activator of tyrosinase and TyrpI genes.". Mol. Endocrinol. 14 (3): 449–56. PMID 10707962.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Davis IJ, Hsi BL, Arroyo JD, et al. (2003). "Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation.". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6051–6. doi:10.1073/pnas.0931430100. PMID 12719541.
Kuiper RP, Schepens M, Thijssen J, et al. (2003). "Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution.". Hum. Mol. Genet. 12 (14): 1661–9. PMID 12837690.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kuiper RP, Schepens M, Thijssen J, et al. (2004). "Regulation of the MiTF/TFE bHLH-LZ transcription factors through restricted spatial expression and alternative splicing of functional domains.". Nucleic Acids Res. 32 (8): 2315–22. doi:10.1093/nar/gkh571. PMID 15118077.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Argani P, Laé M, Hutchinson B, et al. (2005). "Renal carcinomas with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCR.". Am. J. Surg. Pathol. 29 (2): 230–40. PMID 15644781.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Pecciarini L, Cangi MG, Lo Cunsolo C, et al. (2007). "Characterization of t(6;11)(p21;q12) in a renal-cell carcinoma of an adult patient.". Genes Chromosomes Cancer 46 (5): 419–26. doi:10.1002/gcc.20422. PMID 17285572.