TFCP2

From Wikipedia, the free encyclopedia

Transcription factor CP2

Identifiers

TFCP2; CP2; LBP-1C; LSF; SEF; TFCP2C

External IDs

OMIM: 189889 MGI: 98509 HomoloGene: 4134

Gene ontology
Molecular Function:	• transcription factor activity
Cellular Component:	• cellular_component • nucleus
Biological Process:	• transcription • regulation of transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005653 (mRNA)
NP_005644 (protein)

NM_033476 (mRNA)
NP_258437 (protein)

Location

Chr 12: 49.77 - 49.85 Mb

Chr 15: 100.33 - 100.38 Mb

Pubmed search

[1]

[2]

Transcription factor CP2, also known as TFCP2, is a human gene.^[1]

[edit] References

^ Entrez Gene: TFCP2 transcription factor CP2.

[edit] Further reading

Lim LC, Swendeman SL, Sheffery M (1992). "Molecular cloning of the alpha-globin transcription factor CP2.". Mol. Cell. Biol. 12 (2): 828–35. PMID 1732747.
Jane SM, Nienhuis AW, Cunningham JM (1995). "Hemoglobin switching in man and chicken is mediated by a heteromeric complex between the ubiquitous transcription factor CP2 and a developmentally specific protein.". EMBO J. 14 (1): 97–105. PMID 7828600.
Shirra MK, Zhu Q, Huang HC, et al. (1994). "One exon of the human LSF gene includes conserved regions involved in novel DNA-binding and dimerization motifs.". Mol. Cell. Biol. 14 (8): 5076–87. PMID 8035790.
Yoon JB, Li G, Roeder RG (1994). "Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro.". Mol. Cell. Biol. 14 (3): 1776–85. PMID 8114710.
Swendeman SL, Spielholz C, Jenkins NA, et al. (1994). "Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2.". J. Biol. Chem. 269 (15): 11663–71. PMID 8157699.
Margolis DM, Somasundaran M, Green MR (1994). "Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production.". J. Virol. 68 (2): 905–10. PMID 8289393.
Cunningham JM, Vanin EF, Tran N, et al. (1996). "The human transcription factor CP2 (TFCP2), a component of the human gamma-globin stage selector protein, maps to chromosome region 12q13 and is within 250 kb of the NF-E2 gene.". Genomics 30 (2): 398–9. PMID 8586452.
Romerio F, Gabriel MN, Margolis DM (1997). "Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF.". J. Virol. 71 (12): 9375–82. PMID 9371597.
Zambrano N, Minopoli G, de Candia P, Russo T (1998). "The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1.". J. Biol. Chem. 273 (32): 20128–33. PMID 9685356.
Bing Z, Reddy SA, Ren Y, et al. (1999). "Purification and characterization of the serum amyloid A3 enhancer factor.". J. Biol. Chem. 274 (35): 24649–56. PMID 10455131.
Coull JJ, Romerio F, Sun JM, et al. (2000). "The human factors YY1 and LSF repress the human immunodeficiency virus type 1 long terminal repeat via recruitment of histone deacetylase 1.". J. Virol. 74 (15): 6790–9. PMID 10888618.
Zhou W, Clouston DR, Wang X, et al. (2000). "Induction of human fetal globin gene expression by a novel erythroid factor, NF-E4.". Mol. Cell. Biol. 20 (20): 7662–72. PMID 11003662.
Rodda S, Sharma S, Scherer M, et al. (2001). "CRTR-1, a developmentally regulated transcriptional repressor related to the CP2 family of transcription factors.". J. Biol. Chem. 276 (5): 3324–32. doi:10.1074/jbc.M008167200. PMID 11073954.
Zheng JB, Zhou YH, Maity T, et al. (2001). "Activation of the human PAX6 gene through the exon 1 enhancer by transcription factors SEF and Sp1.". Nucleic Acids Res. 29 (19): 4070–8. PMID 11574690.
Tuckfield A, Clouston DR, Wilanowski TM, et al. (2002). "Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors.". Mol. Cell. Biol. 22 (6): 1936–46. PMID 11865070.
He G, Margolis DM (2002). "Counterregulation of chromatin deacetylation and histone deacetylase occupancy at the integrated promoter of human immunodeficiency virus type 1 (HIV-1) by the HIV-1 repressor YY1 and HIV-1 activator Tat.". Mol. Cell. Biol. 22 (9): 2965–73. PMID 11940654.
Peters LM, Anderson DW, Griffith AJ, et al. (2003). "Mutation of a transcription factor, TFCP2L3, causes progressive autosomal dominant hearing loss, DFNA28.". Hum. Mol. Genet. 11 (23): 2877–85. PMID 12393799.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Luedecking-Zimmer E, DeKosky ST, Nebes R, Kamboh MI (2003). "Association of the 3' UTR transcription factor LBP-1c/CP2/LSF polymorphism with late-onset Alzheimer's disease.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 117 (1): 114–7. doi:10.1002/ajmg.b.10026. PMID 12555245.
Chae JH, Kim CG (2003). "CP2 binding to the promoter is essential for the enhanced transcription of globin genes in erythroid cells.". Mol. Cells 15 (1): 40–7. PMID 12661759.