Testicular receptor 4

From Wikipedia, the free encyclopedia


Nuclear receptor subfamily 2, group C, member 2
Identifiers
Symbol(s) NR2C2; TAK1; TR2R1; TR4; hTAK1
External IDs OMIM: 601426 MGI: 1352466 HomoloGene: 2475
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7182 22026
Ensembl ENSG00000177463 ENSMUSG00000005893
Uniprot P49116 Q3U015
Refseq NM_003298 (mRNA)
NP_003289 (protein)		 XM_984385 (mRNA)
XP_989479 (protein)
Location Chr 3: 15.02 - 15.06 Mb Chr 6: 92.1 - 92.13 Mb
Pubmed search [1] [2]

Testicular receptor 4 is a member of the nuclear receptor family of transcription factors and is encoded by the NR2C2 gene (nuclear receptor subfamily 2, group C, member 2).[1]

[edit] See also

[edit] References

  1. ^ Entrez Gene: NR2C2.

[edit] Further reading

  • Hirose T, Fujimoto W, Tamaai T, et al. (1995). "TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily.". Mol. Endocrinol. 8 (12): 1667–80. PMID 7708055. 
  • Chang C, Da Silva SL, Ideta R, et al. (1994). "Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily.". Proc. Natl. Acad. Sci. U.S.A. 91 (13): 6040–4. PMID 8016112. 
  • Yoshikawa T, DuPont BR, Leach RJ, Detera-Wadleigh SD (1996). "New variants of the human and rat nuclear hormone receptor, TR4: expression and chromosomal localization of the human gene.". Genomics 35 (2): 361–6. doi:10.1006/geno.1996.0368. PMID 8661150. 
  • Young WJ, Smith SM, Chang C (1997). "Induction of the intronic enhancer of the human ciliary neurotrophic factor receptor (CNTFRalpha) gene by the TR4 orphan receptor. A member of steroid receptor superfamily.". J. Biol. Chem. 272 (5): 3109–16. PMID 9006963. 
  • Lee CH, Chinpaisal C, Wei LN (1998). "A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4.". J. Biol. Chem. 273 (39): 25209–15. PMID 9737983. 
  • Lee YF, Shyr CR, Thin TH, et al. (2000). "Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily.". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14724–9. PMID 10611280. 
  • Wang X, Yeh S, Wu G, et al. (2001). "Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells.". J. Biol. Chem. 276 (44): 40417–23. doi:10.1074/jbc.M104765200. PMID 11509567. 
  • Yeung KC, Rose DW, Dhillon AS, et al. (2001). "Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation.". Mol. Cell. Biol. 21 (21): 7207–17. doi:10.1128/MCB.21.21.7207-7217.2001. PMID 11585904. 
  • Shyr CR, Hu YC, Kim E, Chang C (2002). "Modulation of estrogen receptor-mediated transactivation by orphan receptor TR4 in MCF-7 cells.". J. Biol. Chem. 277 (17): 14622–8. doi:10.1074/jbc.M110051200. PMID 11844790. 
  • Tanabe O, Katsuoka F, Campbell AD, et al. (2002). "An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer.". EMBO J. 21 (13): 3434–42. doi:10.1093/emboj/cdf340. PMID 12093744. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Yang Y, Wang X, Dong T, et al. (2003). "Identification of a novel testicular orphan receptor-4 (TR4)-associated protein as repressor for the selective suppression of TR4-mediated transactivation.". J. Biol. Chem. 278 (9): 7709–17. doi:10.1074/jbc.M207116200. PMID 12486131. 
  • Lin WJ, Li J, Lee YF, et al. (2003). "Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4.". J. Biol. Chem. 278 (11): 9353–60. doi:10.1074/jbc.M205944200. PMID 12522137. 
  • Takaesu G, Surabhi RM, Park KJ, et al. (2003). "TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway.". J. Mol. Biol. 326 (1): 105–15. PMID 12547194. 
  • Inui S, Lee YF, Chang E, et al. (2003). "Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes.". J. Dermatol. Sci. 31 (1): 65–71. PMID 12615366. 
  • Ishitani T, Takaesu G, Ninomiya-Tsuji J, et al. (2004). "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling.". EMBO J. 22 (23): 6277–88. doi:10.1093/emboj/cdg605. PMID 14633987. 
  • Cheung PC, Nebreda AR, Cohen P (2004). "TAB3, a new binding partner of the protein kinase TAK1.". Biochem. J. 378 (Pt 1): 27–34. doi:10.1042/BJ20031794. PMID 14670075. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. 
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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD