Testicular receptor 2

From Wikipedia, the free encyclopedia


Nuclear receptor subfamily 2, group C, member 1
Identifiers
Symbol(s) NR2C1; TR2; TR2-11
External IDs OMIM: 601529 MGI: 1352465 HomoloGene: 55731
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7181 22025
Ensembl ENSG00000120798 ENSMUSG00000005897
Uniprot P13056 Q0VGP8
Refseq NM_001032287 (mRNA)
NP_001027458 (protein)		 NM_011629 (mRNA)
NP_035759 (protein)
Location Chr 12: 93.94 - 93.99 Mb Chr 10: 93.58 - 93.63 Mb
Pubmed search [1] [2]

The testicular receptor 2 (TR2) is a member of the nuclear receptor family of transcription factors. TR2 is encoded by the NR2C1 gene (nuclear receptor subfamily 2, group C, member 1).[1]


[edit] See also

[edit] References

  1. ^ Entrez Gene: NR2C1 nuclear receptor subfamily 2, group C, member 1.

[edit] Further reading

  • Chang C, Kokontis J, Acakpo-Satchivi L, et al. (1990). "Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains.". Biochem. Biophys. Res. Commun. 165 (2): 735–41. PMID 2597158. 
  • Chang C, Kokontis J (1988). "Identification of a new member of the steroid receptor super-family by cloning and sequence analysis.". Biochem. Biophys. Res. Commun. 155 (2): 971–7. PMID 3421977. 
  • Lin DL, Wu SQ, Chang C (1998). "The genomic structure and chromosomal location of the human TR2 orphan receptor, a member of the steroid receptor superfamily.". Endocrine 8 (2): 123–34. PMID 9704569. 
  • Lee CH, Chinpaisal C, Wei LN (1998). "A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4.". J. Biol. Chem. 273 (39): 25209–15. PMID 9737983. 
  • Lee CH, Chinpaisal C, Wei LN (1998). "Cloning and characterization of mouse RIP140, a corepressor for nuclear orphan receptor TR2.". Mol. Cell. Biol. 18 (11): 6745–55. PMID 9774688. 
  • Yu Z, Lee CH, Chinpaisal C, Wei LN (1999). "A constitutive nuclear localization signal from the second zinc-finger of orphan nuclear receptor TR2.". J. Endocrinol. 159 (1): 53–60. PMID 9795341. 
  • Franco PJ, Farooqui M, Seto E, Wei LN (2001). "The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases.". Mol. Endocrinol. 15 (8): 1318–28. PMID 11463856. 
  • Tanabe O, Katsuoka F, Campbell AD, et al. (2002). "An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer.". EMBO J. 21 (13): 3434–42. doi:10.1093/emboj/cdf340. PMID 12093744. 
  • Hu YC, Shyr CR, Che W, et al. (2002). "Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor.". J. Biol. Chem. 277 (37): 33571–9. doi:10.1074/jbc.M203531200. PMID 12093804. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Inui S, Lee YF, Chang E, et al. (2003). "Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes.". J. Dermatol. Sci. 31 (1): 65–71. PMID 12615366. 
  • Franco PJ, Li G, Wei LN (2004). "Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase.". Mol. Cell. Endocrinol. 206 (1-2): 1–12. PMID 12943985. 
  • Mu X, Chang C (2003). "TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3.". Prostate 57 (2): 129–33. doi:10.1002/pros.10282. PMID 12949936. 
  • Li G, Franco PJ, Wei LN (2003). "Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2.". Biochem. Biophys. Res. Commun. 310 (2): 384–90. PMID 14521922. 
  • Lin YL, Wang YH, Lee HJ (2006). "Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A.". Biochem. Biophys. Res. Commun. 350 (2): 430–6. doi:10.1016/j.bbrc.2006.09.061. PMID 17010934. 
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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD