TESK2

From Wikipedia, the free encyclopedia

Testis-specific kinase 2

Identifiers

External IDs

OMIM: 604746 MGI: 2385204 HomoloGene: 5188

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • protein serine/threonine kinase activity • protein-tyrosine kinase activity • ATP binding • transferase activity • manganese ion binding
Cellular Component:	• nucleus
Biological Process:	• protein amino acid phosphorylation • apoptosis • intracellular signaling cascade • spermatogenesis • actin cytoskeleton organization and biogenesis • focal adhesion formation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007170 (mRNA)
NP_009101 (protein)

NM_146151 (mRNA)
NP_666263 (protein)

Location

Chr 1: 45.58 - 45.73 Mb

Chr 4: 116.22 - 116.3 Mb

Pubmed search

[1]

[2]

Testis-specific kinase 2, also known as TESK2, is a human gene.^[1]

This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis.^[1]

[edit] References

^ ^a ^b Entrez Gene: TESK2 testis-specific kinase 2.

[edit] Further reading

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Toshima JY, Toshima J, Watanabe T, Mizuno K (2001). "Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1.". J. Biol. Chem. 276 (46): 43471-81. doi:10.1074/jbc.M104620200. PMID 11555644.
Toshima J, Toshima JY, Takeuchi K, et al. (2001). "Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells.". J. Biol. Chem. 276 (33): 31449-58. doi:10.1074/jbc.M102988200. PMID 11418599.
Røsok O, Pedeutour F, Ree AH, Aasheim HC (1999). "Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis.". Genomics 61 (1): 44-54. doi:10.1006/geno.1999.5922. PMID 10512679.