TESK1

From Wikipedia, the free encyclopedia

Testis-specific kinase 1
Identifiers
Symbol(s)	TESK1;
External IDs	OMIM: 601782 MGI: 1201675 HomoloGene: 4577
Gene ontology Molecular Function: • nucleotide binding • magnesium ion binding • protein serine/threonine kinase activity • protein-tyrosine kinase activity • protein binding • ATP binding • kinase activity • transferase activity • manganese ion binding Biological Process: • protein amino acid phosphorylation • spermatogenesis
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	7016	21754
Ensembl	ENSG00000107140	ENSMUSG00000028458
Uniprot	Q15569	Q499W7
Refseq	NM_006285 (mRNA) NP_006276 (protein)	XM_973123 (mRNA) XP_978217 (protein)
Location	Chr 9: 35.6 - 35.6 Mb	Chr 4: 43.46 - 43.47 Mb
Pubmed search	[1]	[2]

Testis-specific kinase 1, also known as TESK1, is a human gene.^[1]

This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis.^[1]

[edit] References

[edit] Further reading