Terlipressin
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Terlipressin
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| Systematic (IUPAC) name | |
| (2S)-1-[(4S,7S,10S,13S,16S,19S)-19-[[2- [[2-[(2-Aminoacetyl)amino]acetyl]amino] acetyl]amino]-13-benzyl-10-(2-carbamoylethyl)- 7-(carbamoylmethyl)-16-[(4-hydroxyphenyl) methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8, 11,14,17-pentazacycloicosane-4-carbonyl]-N- [(1S)-5-amino-1-(carbamoylmethylcarbamoyl) pentyl]pyrrolidine-2-carboxamide |
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| Identifiers | |
| CAS number | |
| ATC code | H01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C52H74N16O15S2 |
| Mol. mass | 1227.37 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | ~30% |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | IV |
Terlipressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It has been found to be effective when norepinephrine does not help.
Indications for use include norepinephrine-resistant septic shock[1] and hepatorenal syndrome.[2] In addition, it is used in bleeding esophageal varices.[3]
Terlipressin is marketed under the brand name Glypressin (Ferring Pharmaceuticals).
[edit] See also
[edit] References
- ^ O'Brien A, Clapp L, Singer M (2002). "Terlipressin for norepinephrine-resistant septic shock". Lancet 359 (9313): 1209–10. doi:. PMID 11955542.
- ^ Uriz J, Ginès P, Cárdenas A, Sort P, Jiménez W, Salmerón J, Bataller R, Mas A, Navasa M, Arroyo V, Rodés J (2000). "Terlipressin plus albumin infusion: an effective and safe therapy of hepatorenal syndrome". J Hepatol 33 (1): 43–8. doi:. PMID 10905585.
- ^ Ioannou G, Doust J, Rockey D. "Terlipressin for acute esophageal variceal hemorrhage". Cochrane Database Syst Rev: CD002147. doi:. PMID 12535432.
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