Terazosin

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Terazosin
Systematic (IUPAC) name
[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl) piperazin-1-yl]- tetrahydrofuran-2-yl-methanone
Identifiers
CAS number	63590-64-7
ATC code	G04CA03
PubChem	5401
DrugBank	APRD00667
Chemical data
Formula	C19H25N5O4
Mol. mass	387.433 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	90-94%
Metabolism	?
Half life	12 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Terazosin (Hytrin) is a selective alpha 1 antagonist used for treatment of symptoms of an enlarged prostate (BPH). It also acts to lower the blood pressure, and is therefore a drug of choice for men with hypertension and prostate enlargement.

It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.

Most common side effects include dizziness, drowsiness, headache, constipation, loss of appetite, fatigue, nasal congestion or dry eyes, but they generally go away after only a few days of use. Therapy should always be started with a low dose to avoid first dose phenomenon.^[1] Sexual side effects are rare, but may include priapism or erectile dysfunction.

[edit] References

1. ^ Hytrin (Terazosin Hcl) drug warnings and precautions - prescription drugs and medications at RxList

v • d • e Urologicals (G04) Acidifiers Ammonium chloride, Calcium chloride Urinary antispasmodics (primarily antimuscarinics) Darifenacin, Emepronium, Fenoverine, Fesoterodine, Flavoxate, Meladrazine, Oxybutynin, Propiverine, Solifenacin, Terodiline, Tolterodine, Trospium For erectile dysfunction prostaglandins: Alprostadil PDE5 inhibitors: Avanafil - Sildenafil - Tadalafil - Udenafil - Vardenafil alpha blockers: Moxisylyte - Phentolamine - Yohimbine others: Apomorphine - Papaverine Other urologicals Acetohydroxamic acid, Collagen, Dimethyl sulfoxide, Magnesium hydroxide, Pentosan polysulfate, Phenazopyridine, Phenyl salicylate, Succinimide For benign prostatic hypertrophy 5α-reductase inhibitors: Dutasteride, Finasteride Alpha blockers: Alfuzosin, Doxazosin, Silodosin, Tamsulosin, Terazosin Herbals: Pygeum africanum, Serenoa repens