TERF2

From Wikipedia, the free encyclopedia

Telomeric repeat binding factor 2

PDB rendering based on 1h6p.

Available structures: 1h6p, 1vf9, 1vfc, 1w0u, 1xg1

Identifiers

Symbol(s)

TERF2; TRBF2; TRF2

External IDs

OMIM: 602027 MGI: 1195972 HomoloGene: 4133

Gene ontology
Molecular Function:	• DNA binding • protein binding • single-stranded telomeric DNA binding
Cellular Component:	• chromosome, telomeric region • nucleus • chromosome
Biological Process:	• telomere maintenance via telomerase • cell cycle • regulation of transcription

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005652 (mRNA)
NP_005643 (protein)

NM_009353 (mRNA)
NP_033379 (protein)

Location

Chr 16: 67.95 - 67.98 Mb

Chr 8: 109.96 - 109.99 Mb

Pubmed search

[1]

[2]

Telomeric repeat binding factor 2, also known as TERF2, is a human gene.

This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.^[1]

[edit] References

^ Entrez Gene: TERF2 telomeric repeat binding factor 2.

Bilaud T, Koering CE, Binet-Brasselet E, et al. (1996). "The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human.". Nucleic Acids Res. 24 (7): 1294–303. PMID 8614633.
Broccoli D, Smogorzewska A, Chong L, de Lange T (1997). "Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2.". Nat. Genet. 17 (2): 231–5. doi:10.1038/ng1097-231. PMID 9326950.
Bilaud T, Brun C, Ancelin K, et al. (1997). "Telomeric localization of TRF2, a novel human telobox protein.". Nat. Genet. 17 (2): 236–9. doi:10.1038/ng1097-236. PMID 9326951.
van Steensel B, Smogorzewska A, de Lange T (1998). "TRF2 protects human telomeres from end-to-end fusions.". Cell 92 (3): 401–13. PMID 9476899.
Sakaguchi AY, Padalecki SS, Mattern V, et al. (1999). "Chromosomal sublocalization of the transcribed human telomere repeat binding factor 2 gene and comparative mapping in the mouse.". Somat. Cell Mol. Genet. 24 (3): 157–63. PMID 10226653.
Griffith JD, Comeau L, Rosenfield S, et al. (1999). "Mammalian telomeres end in a large duplex loop.". Cell 97 (4): 503–14. PMID 10338214.
Teichmann M, Wang Z, Martinez E, et al. (2000). "Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells.". Proc. Natl. Acad. Sci. U.S.A. 96 (24): 13720–5. PMID 10570139.
Smogorzewska A, van Steensel B, Bianchi A, et al. (2000). "Control of human telomere length by TRF1 and TRF2.". Mol. Cell. Biol. 20 (5): 1659–68. PMID 10669743.
Li B, Oestreich S, de Lange T (2000). "Identification of human Rap1: implications for telomere evolution.". Cell 101 (5): 471–83. PMID 10850490.
Zhu XD, Küster B, Mann M, et al. (2000). "Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres.". Nat. Genet. 25 (3): 347–52. doi:10.1038/77139. PMID 10888888.
Song K, Jung D, Jung Y, et al. (2000). "Interaction of human Ku70 with TRF2.". FEBS Lett. 481 (1): 81–5. PMID 10984620.
Song K, Jung Y, Jung D, Lee I (2001). "Human Ku70 interacts with heterochromatin protein 1alpha.". J. Biol. Chem. 276 (11): 8321–7. doi:10.1074/jbc.M008779200. PMID 11112778.
Fairall L, Chapman L, Moss H, et al. (2001). "Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2.". Mol. Cell 8 (2): 351–61. PMID 11545737.
Bailey SM, Cornforth MN, Kurimasa A, et al. (2001). "Strand-specific postreplicative processing of mammalian telomeres.". Science 293 (5539): 2462–5. doi:10.1126/science.1062560. PMID 11577237.
Karlseder J, Smogorzewska A, de Lange T (2002). "Senescence induced by altered telomere state, not telomere loss.". Science 295 (5564): 2446–9. doi:10.1126/science.1069523. PMID 11923537.
Mignon-Ravix C, Depetris D, Delobel B, et al. (2002). "A human interstitial telomere associates in vivo with specific TRF2 and TIN2 proteins.". Eur. J. Hum. Genet. 10 (2): 107–12. doi:10.1038/sj.ejhg.5200775. PMID 11938440.
Ancelin K, Brunori M, Bauwens S, et al. (2002). "Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2.". Mol. Cell. Biol. 22 (10): 3474–87. PMID 11971978.
Opresko PL, von Kobbe C, Laine JP, et al. (2002). "Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases.". J. Biol. Chem. 277 (43): 41110–9. doi:10.1074/jbc.M205396200. PMID 12181313.
Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis.". Am. J. Hum. Genet. 71 (6): 1443–9. PMID 12417987.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.