TERF1

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Telomeric repeat binding factor (NIMA-interacting) 1
PDB rendering based on 1ba5.
Available structures: 1ba5, 1h6o, 1ity, 1iv6, 1w0t
Identifiers
Symbol(s) TERF1; TRF; FLJ41416; PIN2; TRBF1; TRF1; hTRF1-AS; t-TRF1
External IDs OMIM: 600951 MGI: 109634 HomoloGene: 7570
Orthologs
Human Mouse
Entrez 7013 21749
Ensembl n/a ENSMUSG00000025925
Uniprot n/a Q7TSK8
Refseq NM_003218 (mRNA)
NP_003209 (protein)		 NM_009352 (mRNA)
NP_033378 (protein)
Location n/a Chr 1: 15.79 - 15.83 Mb
Pubmed search [1] [2]

Telomeric repeat binding factor (NIMA-interacting) 1, also known as TERF1, is a human gene.[1]

This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products.[1]

[edit] References

  1. ^ a b Entrez Gene: TERF1 telomeric repeat binding factor (NIMA-interacting) 1.

[edit] Further reading

  • Zhong Z, Shiue L, Kaplan S, de Lange T (1992). "A mammalian factor that binds telomeric TTAGGG repeats in vitro.". Mol. Cell. Biol. 12 (11): 4834–43. PMID 1406665. 
  • Chong L, van Steensel B, Broccoli D, et al. (1996). "A human telomeric protein.". Science 270 (5242): 1663–7. PMID 7502076. 
  • Lu KP, Hanes SD, Hunter T (1996). "A human peptidyl-prolyl isomerase essential for regulation of mitosis.". Nature 380 (6574): 544–7. doi:10.1038/380544a0. PMID 8606777. 
  • Bilaud T, Koering CE, Binet-Brasselet E, et al. (1996). "The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human.". Nucleic Acids Res. 24 (7): 1294–303. PMID 8614633. 
  • Broccoli D, Chong L, Oelmann S, et al. (1997). "Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression and conserved protein domains.". Hum. Mol. Genet. 6 (1): 69–76. PMID 9002672. 
  • Bianchi A, Smith S, Chong L, et al. (1997). "TRF1 is a dimer and bends telomeric DNA.". EMBO J. 16 (7): 1785–94. doi:10.1093/emboj/16.7.1785. PMID 9130722. 
  • Broccoli D, Smogorzewska A, Chong L, de Lange T (1997). "Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2.". Nat. Genet. 17 (2): 231–5. doi:10.1038/ng1097-231. PMID 9326950. 
  • Shen M, Haggblom C, Vogt M, et al. (1998). "Characterization and cell cycle regulation of the related human telomeric proteins Pin2 and TRF1 suggest a role in mitosis.". Proc. Natl. Acad. Sci. U.S.A. 94 (25): 13618–23. PMID 9391075. 
  • Nosaka K, Kawahara M, Masuda M, et al. (1998). "Association of nucleoside diphosphate kinase nm23-H2 with human telomeres.". Biochem. Biophys. Res. Commun. 243 (2): 342–8. doi:10.1006/bbrc.1997.8097. PMID 9480811. 
  • Nishikawa T, Nagadoi A, Yoshimura S, et al. (1998). "Solution structure of the DNA-binding domain of human telomeric protein, hTRF1.". Structure 6 (8): 1057–65. PMID 9739097. 
  • Smith S, Giriat I, Schmitt A, de Lange T (1998). "Tankyrase, a poly(ADP-ribose) polymerase at human telomeres.". Science 282 (5393): 1484–7. PMID 9822378. 
  • Kim SH, Kaminker P, Campisi J (1999). "TIN2, a new regulator of telomere length in human cells.". Nat. Genet. 23 (4): 405–12. doi:10.1038/70508. PMID 10581025. 
  • Smogorzewska A, van Steensel B, Bianchi A, et al. (2000). "Control of human telomere length by TRF1 and TRF2.". Mol. Cell. Biol. 20 (5): 1659–68. PMID 10669743. 
  • Wu G, Lee WH, Chen PL (2000). "NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres.". J. Biol. Chem. 275 (39): 30618–22. doi:10.1074/jbc.C000390200. PMID 10913111. 
  • Chi NW, Lodish HF (2001). "Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles.". J. Biol. Chem. 275 (49): 38437–44. doi:10.1074/jbc.M007635200. PMID 10988299. 
  • Kishi S, Wulf G, Nakamura M, Lu KP (2001). "Telomeric protein Pin2/TRF1 induces mitotic entry and apoptosis in cells with short telomeres and is down-regulated in human breast tumors.". Oncogene 20 (12): 1497–508. doi:10.1038/sj.onc.1204229. PMID 11313893. 
  • Kishi S, Zhou XZ, Ziv Y, et al. (2001). "Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks.". J. Biol. Chem. 276 (31): 29282–91. doi:10.1074/jbc.M011534200. PMID 11375976. 
  • Fairall L, Chapman L, Moss H, et al. (2001). "Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2.". Mol. Cell 8 (2): 351–61. PMID 11545737. 
  • Zhou XZ, Lu KP (2001). "The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor.". Cell 107 (3): 347–59. PMID 11701125. 
  • Nishikawa T, Okamura H, Nagadoi A, et al. (2002). "Solution structure of a telomeric DNA complex of human TRF1.". Structure 9 (12): 1237–51. PMID 11738049. 
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