Tenascin C

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Tenascin C (hexabrachion)
PDB rendering based on 1ten.
Available structures: 1ten
Identifiers
Symbol(s) TNC; HXB; TN
External IDs OMIM: 187380 MGI: 101922 HomoloGene: 55636
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3371 21923
Ensembl ENSG00000041982 ENSMUSG00000028364
Uniprot P24821 Q80YX0
Refseq NM_002160 (mRNA)
NP_002151 (protein)		 NM_011607 (mRNA)
NP_035737 (protein)
Location Chr 9: 116.82 - 116.92 Mb Chr 4: 63.45 - 63.53 Mb
Pubmed search [1] [2]

Tenascin C (hexabrachion), also known as TNC, is a human gene.


[edit] See also

[edit] Further reading

  • Imanaka-Yoshida K, Hiroe M, Yoshida T (2004). "Interaction between cell and extracellular matrix in heart disease: multiple roles of tenascin-C in tissue remodeling.". Histol. Histopathol. 19 (2): 517–25. PMID 15024713. 
  • Leahy DJ, Hendrickson WA, Aukhil I, Erickson HP (1992). "Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein.". Science 258 (5084): 987–91. PMID 1279805. 
  • White DM, Mikol DD, Espinosa R, et al. (1992). "Structure and chromosomal localization of the human gene for a brain form of prostaglandin D2 synthase.". J. Biol. Chem. 267 (32): 23202–8. PMID 1385416. 
  • Nies DE, Hemesath TJ, Kim JH, et al. (1991). "The complete cDNA sequence of human hexabrachion (Tenascin). A multidomain protein containing unique epidermal growth factor repeats.". J. Biol. Chem. 266 (5): 2818–23. PMID 1704365. 
  • Siri A, Carnemolla B, Saginati M, et al. (1991). "Human tenascin: primary structure, pre-mRNA splicing patterns and localization of the epitopes recognized by two monoclonal antibodies.". Nucleic Acids Res. 19 (3): 525–31. PMID 1707164. 
  • Gulcher JR, Nies DE, Alexakos MJ, et al. (1991). "Structure of the human hexabrachion (tenascin) gene.". Proc. Natl. Acad. Sci. U.S.A. 88 (21): 9438–42. PMID 1719530. 
  • Gulcher JR, Nies DE, Marton LS, Stefansson K (1989). "An alternatively spliced region of the human hexabrachion contains a repeat of potential N-glycosylation sites.". Proc. Natl. Acad. Sci. U.S.A. 86 (5): 1588–92. PMID 2466295. 
  • Chung CY, Zardi L, Erickson HP (1996). "Binding of tenascin-C to soluble fibronectin and matrix fibrils.". J. Biol. Chem. 270 (48): 29012–7. PMID 7499434. 
  • Yokosaki Y, Palmer EL, Prieto AL, et al. (1994). "The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin.". J. Biol. Chem. 269 (43): 26691–6. PMID 7523411. 
  • Glumoff V, Savontaus M, Vehanen J, Vuorio E (1994). "Analysis of aggrecan and tenascin gene expression in mouse skeletal tissues by northern and in situ hybridization using species specific cDNA probes.". Biochim. Biophys. Acta 1219 (3): 613–22. PMID 7524681. 
  • Gherzi R, Carnemolla B, Siri A, et al. (1995). "Human tenascin gene. Structure of the 5'-region, identification, and characterization of the transcription regulatory sequences.". J. Biol. Chem. 270 (7): 3429–34. PMID 7531707. 
  • Weinacker A, Ferrando R, Elliott M, et al. (1995). "Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands, fibronectin and tenascin, in human airways.". Am. J. Respir. Cell Mol. Biol. 12 (5): 547–56. PMID 7537970. 
  • Schnapp LM, Hatch N, Ramos DM, et al. (1995). "The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin.". J. Biol. Chem. 270 (39): 23196–202. PMID 7559467. 
  • Sriramarao P, Mendler M, Bourdon MA (1993). "Endothelial cell attachment and spreading on human tenascin is mediated by alpha 2 beta 1 and alpha v beta 3 integrins.". J. Cell. Sci. 105 ( Pt 4): 1001–12. PMID 7693733. 
  • Prieto AL, Edelman GM, Crossin KL (1993). "Multiple integrins mediate cell attachment to cytotactin/tenascin.". Proc. Natl. Acad. Sci. U.S.A. 90 (21): 10154–8. PMID 7694284. 
  • Zagzag D, Friedlander DR, Dosik J, et al. (1996). "Tenascin-C expression by angiogenic vessels in human astrocytomas and by human brain endothelial cells in vitro.". Cancer Res. 56 (1): 182–9. PMID 8548761. 
  • Yokosaki Y, Monis H, Chen J, Sheppard D (1996). "Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains.". J. Biol. Chem. 271 (39): 24144–50. PMID 8798654. 
  • Burg MA, Tillet E, Timpl R, Stallcup WB (1996). "Binding of the NG2 proteoglycan to type VI collagen and other extracellular matrix molecules.". J. Biol. Chem. 271 (42): 26110–6. PMID 8824254. 
  • Jones PL, Crack J, Rabinovitch M (1998). "Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the alpha v beta 3 integrin to promote epidermal growth factor receptor phosphorylation and growth.". J. Cell Biol. 139 (1): 279–93. PMID 9314546. 
  • Rauch U, Clement A, Retzler C, et al. (1997). "Mapping of a defined neurocan binding site to distinct domains of tenascin-C.". J. Biol. Chem. 272 (43): 26905–12. PMID 9341124. 
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