Telomerase RNA component

From Wikipedia, the free encyclopedia

Merge arrows
 It has been suggested that this article or section be merged with Vertebrate telomerase RNA. (Discuss)


Telomerase RNA component
Identifiers
Symbol(s) TERC; TR; SCARNA19; TRC3; hTR
External IDs OMIM: 602322
Orthologs
Human Mouse
Entrez 7012 n/a



Pubmed search [1] n/a

Telomerase RNA component, also known as TERC, is a human gene.[1]

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component, encoded by this gene, that serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Mutations in this gene cause autosomal dominant dyskeratosis congenita, and may also be associated with some cases of aplastic anemia.[1]

[edit] References

  1. ^ a b Entrez Gene: TERC telomerase RNA component.

[edit] Further reading

  • de Lange T, Jacks T (1999). "For better or worse? Telomerase inhibition and cancer.". Cell 98 (3): 273–5. PMID 10458601. 
  • Marrone A, Dokal I (2007). "Dyskeratosis congenita: molecular insights into telomerase function, ageing and cancer.". Expert reviews in molecular medicine 6 (26): 1–23. doi:10.1017/S1462399404008671. PMID 15613268. 
  • Yamaguchi H (2007). "Mutations of telomerase complex genes linked to bone marrow failures.". Journal of Nippon Medical School = Nihon Ika Daigaku zasshi 74 (3): 202–9. PMID 17625368. 
  • Feng J, Funk WD, Wang SS, et al. (1995). "The RNA component of human telomerase.". Science 269 (5228): 1236–41. PMID 7544491. 
  • Zaug AJ, Linger J, Cech TR (1996). "Method for determining RNA 3' ends and application to human telomerase RNA.". Nucleic Acids Res. 24 (3): 532–3. PMID 8602368. 
  • Soder AI, Hoare SF, Muire S, et al. (1997). "Mapping of the gene for the mouse telomerase RNA component, Terc, to chromosome 3 by fluorescence in situ hybridization and mouse chromosome painting.". Genomics 41 (2): 293–4. doi:10.1006/geno.1997.4621. PMID 9143511. 
  • Zhao JQ, Hoare SF, McFarlane R, et al. (1998). "Cloning and characterization of human and mouse telomerase RNA gene promoter sequences.". Oncogene 16 (10): 1345–50. doi:10.1038/sj.onc.1201892. PMID 9546436. 
  • Mitchell JR, Wood E, Collins K (1999). "A telomerase component is defective in the human disease dyskeratosis congenita.". Nature 402 (6761): 551–5. doi:10.1038/990141. PMID 10591218. 
  • Chen JL, Blasco MA, Greider CW (2000). "Secondary structure of vertebrate telomerase RNA.". Cell 100 (5): 503–14. PMID 10721988. 
  • Wong KK, Chang S, Weiler SR, et al. (2000). "Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation.". Nat. Genet. 26 (1): 85–8. doi:10.1038/79232. PMID 10973255. 
  • Mitchell JR, Collins K (2000). "Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase.". Mol. Cell 6 (2): 361–71. PMID 10983983. 
  • Imoto I, Pimkhaokham A, Fukuda Y, et al. (2001). "SNO is a probable target for gene amplification at 3q26 in squamous-cell carcinomas of the esophagus.". Biochem. Biophys. Res. Commun. 286 (3): 559–65. doi:10.1006/bbrc.2001.5428. PMID 11511096. 
  • Vulliamy T, Marrone A, Goldman F, et al. (2001). "The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita.". Nature 413 (6854): 432–5. doi:10.1038/35096585. PMID 11574891. 
  • Pruzan R, Pongracz K, Gietzen K, et al. (2002). "Allosteric inhibitors of telomerase: oligonucleotide N3'-->P5' phosphoramidates.". Nucleic Acids Res. 30 (2): 559–68. PMID 11788719. 
  • Zhang RG, Zhang RP, Wang XW, Xie H (2004). "Effects of cisplatin on telomerase activity and telomere length in BEL-7404 human hepatoma cells.". Cell Res. 12 (1): 55–62. doi:10.1038/sj.cr.7290110. PMID 11942411. 
  • Yang Y, Chen Y, Zhang C, et al. (2002). "Nucleolar localization of hTERT protein is associated with telomerase function.". Exp. Cell Res. 277 (2): 201–9. PMID 12083802. 
  • Chang JT, Chen YL, Yang HT, et al. (2002). "Differential regulation of telomerase activity by six telomerase subunits.". Eur. J. Biochem. 269 (14): 3442–50. PMID 12135483. 
  • Gavory G, Farrow M, Balasubramanian S (2002). "Minimum length requirement of the alignment domain of human telomerase RNA to sustain catalytic activity in vitro.". Nucleic Acids Res. 30 (20): 4470–80. PMID 12384594. 
  • Sood AK, Coffin J, Jabbari S, et al. (2003). "p53 null mutations are associated with a telomerase negative phenotype in ovarian carcinoma.". Cancer Biol. Ther. 1 (5): 511–7. PMID 12496479. 
 This protein-related article is a stub. You can help Wikipedia by expanding it.