TEC (gene)

From Wikipedia, the free encyclopedia

Tec protein tyrosine kinase

PDB rendering based on 1gl5.

Available structures: 1gl5

Identifiers

Symbol(s)

TEC; MGC126760; MGC126762; PSCTK4

External IDs

OMIM: 600583 MGI: 98662 HomoloGene: 1302

Gene ontology
Molecular Function:	• nucleotide binding • non-membrane spanning protein tyrosine kinase activity • protein binding • ATP binding • zinc ion binding • transferase activity • metal ion binding
Biological Process:	• protein amino acid phosphorylation • protein kinase cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003215 (mRNA)
NP_003206 (protein)

NM_013689 (mRNA)
NP_038717 (protein)

Location

Chr 4: 47.83 - 47.97 Mb

Chr 5: 73.03 - 73.15 Mb

Pubmed search

[1]

[2]

Tec protein tyrosine kinase, also known as TEC, is a human gene.^[1]

The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.^[1]

[edit] References

^ ^a ^b Entrez Gene: TEC tec protein tyrosine kinase.

[edit] Further reading

Mano H (2000). "Tec family of protein-tyrosine kinases: an overview of their structure and function.". Cytokine Growth Factor Rev. 10 (3-4): 267-80. PMID 10647781.
Yang WC, Collette Y, Nunès JA, Olive D (2000). "Tec kinases: a family with multiple roles in immunity.". Immunity 12 (4): 373-82. PMID 10795735.
Mano H, Ishikawa F, Nishida J, et al. (1991). "A novel protein-tyrosine kinase, tec, is preferentially expressed in liver.". Oncogene 5 (12): 1781-6. PMID 2284097.
Tang B, Mano H, Yi T, Ihle JN (1994). "Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding.". Mol. Cell. Biol. 14 (12): 8432-7. PMID 7526158.
Machide M, Mano H, Todokoro K (1995). "Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain.". Oncogene 11 (4): 619-25. PMID 7651724.
Sato K, Mano H, Ariyama T, et al. (1994). "Molecular cloning and analysis of the human Tec protein-tyrosine kinase.". Leukemia 8 (10): 1663-72. PMID 7934162.
Mano H, Yamashita Y, Miyazato A, et al. (1996). "Tec protein-tyrosine kinase is an effector molecule of Lyn protein-tyrosine kinase.". FASEB J. 10 (5): 637-42. PMID 8621063.
Rawlings DJ, Scharenberg AM, Park H, et al. (1996). "Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases.". Science 271 (5250): 822-5. PMID 8629002.
Park H, Wahl MI, Afar DE, et al. (1996). "Regulation of Btk function by a major autophosphorylation site within the SH3 domain.". Immunity 4 (5): 515-25. PMID 8630736.
Ohta Y, Haire RN, Amemiya CT, et al. (1996). "Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene.". Oncogene 12 (4): 937-42. PMID 8632917.
Cory GO, MacCarthy-Morrogh L, Banin S, et al. (1996). "Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways.". J. Immunol. 157 (9): 3791-5. PMID 8892607.
Takahashi-Tezuka M, Hibi M, Fujitani Y, et al. (1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK.". Oncogene 14 (19): 2273-82. doi:10.1038/sj.onc.1201071. PMID 9178903.
Laffargue M, Monnereau L, Tuech J, et al. (1997). "Integrin-dependent tyrosine phoshorylation and cytoskeletal translocation of Tec in thrombin-activated platelets.". Biochem. Biophys. Res. Commun. 238 (1): 247-51. doi:10.1006/bbrc.1997.7269. PMID 9299487.
Ohya K, Kajigaya S, Yamashita Y, et al. (1997). "SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase.". J. Biol. Chem. 272 (43): 27178-82. PMID 9341160.
Kitanaka A, Mano H, Conley ME, Campana D (1998). "Expression and activation of the nonreceptor tyrosine kinase Tec in human B cells.". Blood 91 (3): 940-8. PMID 9446655.
Yamashita Y, Watanabe S, Miyazato A, et al. (1998). "Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription.". Blood 91 (5): 1496-507. PMID 9473212.
Yang WC, Ghiotto M, Barbarat B, Olive D (1999). "The role of Tec protein-tyrosine kinase in T cell signaling.". J. Biol. Chem. 274 (2): 607-17. PMID 9872994.
Yang WC, Olive D (1999). "Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway.". Eur. J. Immunol. 29 (6): 1842-9. PMID 10382746.
Ohya K, Kajigaya S, Kitanaka A, et al. (1999). "Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase.". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 11976-81. PMID 10518561.