TDO2

From Wikipedia, the free encyclopedia

Tryptophan 2,3-dioxygenase

Identifiers

TDO2; TDO; TPH2; TRPO

External IDs

OMIM: 191070 MGI: 1928486 HomoloGene: 4132

Gene ontology
Molecular Function:	• tryptophan 2,3-dioxygenase activity • iron ion binding • oxidoreductase activity • metal ion binding
Biological Process:	• tryptophan metabolic process • neurotransmitter metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005651 (mRNA)
NP_005642 (protein)

NM_019911 (mRNA)
NP_064295 (protein)

Location

Chr 4: 157.04 - 157.06 Mb

Chr 3: 82.04 - 82.06 Mb

Pubmed search

[1]

[2]

Tryptophan 2,3-dioxygenase, also known as TDO2, is a human gene.^[1]

[edit] References

^ Entrez Gene: TDO2 tryptophan 2,3-dioxygenase.

[edit] Further reading

Comings DE, Muhleman D, Dietz GW, Donlon T (1991). "Human tryptophan oxygenase localized to 4q31: possible implications for alcoholism and other behavioral disorders.". Genomics 9 (2): 301-8. PMID 2004780.
Comings DE, Muhleman D, Dietz G, et al. (1996). "Sequence of human tryptophan 2,3-dioxygenase (TDO2): presence of a glucocorticoid response-like element composed of a GTT repeat and an intronic CCCCT repeat.". Genomics 29 (2): 390-6. doi:10.1006/geno.1995.9990. PMID 8666386.
Dick R, Murray BP, Reid MJ, Correia MA (2001). "Structure--function relationships of rat hepatic tryptophan 2,3-dioxygenase: identification of the putative heme-ligating histidine residues.". Arch. Biochem. Biophys. 392 (1): 71-8. doi:10.1006/abbi.2001.2420. PMID 11469796.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Kudo Y, Boyd CA, Sargent IL, Redman CW (2003). "Decreased tryptophan catabolism by placental indoleamine 2,3-dioxygenase in preeclampsia.". Am. J. Obstet. Gynecol. 188 (3): 719-26. PMID 12634647.
Nabi R, Serajee FJ, Chugani DC, et al. (2005). "Association of tryptophan 2,3 dioxygenase gene polymorphism with autism.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 125 (1): 63-8. doi:10.1002/ajmg.b.20147. PMID 14755447.
Guillemin GJ, Smythe G, Takikawa O, Brew BJ (2005). "Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons.". Glia 49 (1): 15-23. doi:10.1002/glia.20090. PMID 15390107.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.". Nat. Methods 2 (8): 591-8. doi:10.1038/nmeth776. PMID 16094384.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Baharvand H, Hashemi SM, Kazemi Ashtiani S, Farrokhi A (2006). "Differentiation of human embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro.". Int. J. Dev. Biol. 50 (7): 645-52. doi:10.1387/ijdb.052072hb. PMID 16892178.