TCL1A

From Wikipedia, the free encyclopedia

T-cell leukemia/lymphoma 1A

PDB rendering based on 1jsg.

Available structures: 1jsg

Identifiers

Symbol(s)

TCL1A; TCL1

External IDs

OMIM: 186960 MGI: 1097166 HomoloGene: 7565

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• endoplasmic reticulum • microsome • cell cortex • pronucleus
Biological Process:	• multicellular organismal development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021966 (mRNA)
NP_068801 (protein)

NM_009337 (mRNA)
NP_033363 (protein)

Location

Chr 14: 95.25 - 95.25 Mb

Chr 12: 105.62 - 105.62 Mb

Pubmed search

[1]

[2]

T-cell leukemia/lymphoma 1A, also known as TCL1A, is a human gene.^[1] It is encoding a TCL GTPase.

[edit] References

^ Entrez Gene: TCL1A T-cell leukemia/lymphoma 1A.

[edit] Further reading

Pekarsky Y, Hallas C, Croce CM (2001). "The role of TCL1 in human T-cell leukemia.". Oncogene 20 (40): 5638-43. doi:10.1038/sj.onc.1204596. PMID 11607815.
Pekarsky Y, Zanesi N, Aqeilan R, Croce CM (2004). "Tcl1 as a model for lymphomagenesis.". Hematol. Oncol. Clin. North Am. 18 (4): 863-79, ix. doi:10.1016/j.hoc.2004.04.007. PMID 15325703.
Noguchi M, Ropars V, Roumestand C, Suizu F (2007). "Proto-oncogene TCL1: more than just a coactivator for Akt.". FASEB J. 21 (10): 2273-84. doi:10.1096/fj.06-7684com. PMID 17360849.
Russo G, Isobe M, Gatti R, et al. (1989). "Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient.". Proc. Natl. Acad. Sci. U.S.A. 86 (2): 602-6. PMID 2783489.
Virgilio L, Narducci MG, Isobe M, et al. (1995). "Identification of the TCL1 gene involved in T-cell malignancies.". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12530-4. PMID 7809072.
Fu TB, Virgilio L, Narducci MG, et al. (1995). "Characterization and localization of the TCL-1 oncogene product.". Cancer Res. 54 (24): 6297-301. PMID 7987816.
Hoh F, Yang YS, Guignard L, et al. (1998). "Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology.". Structure 6 (2): 147-55. PMID 9519406.
Takizawa J, Suzuki R, Kuroda H, et al. (1998). "Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.". Jpn. J. Cancer Res. 89 (7): 712-8. PMID 9738977.
Pekarsky Y, Hallas C, Isobe M, et al. (1999). "Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes.". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2949-51. PMID 10077617.
Laine J, Künstle G, Obata T, et al. (2000). "The protooncogene TCL1 is an Akt kinase coactivator.". Mol. Cell 6 (2): 395-407. PMID 10983986.
Laine J, Künstle G, Obata T, Noguchi M (2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family.". J. Biol. Chem. 277 (5): 3743-51. doi:10.1074/jbc.M107069200. PMID 11707444.
French SW, Shen RR, Koh PJ, et al. (2002). "A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane.". Biochemistry 41 (20): 6376-82. PMID 12009899.
Fears S, Chakrabarti SR, Nucifora G, Rowley JD (2002). "Differential expression of TCL1 during pre-B-cell acute lymphoblastic leukemia progression.". Cancer Genet. Cytogenet. 135 (2): 110-9. PMID 12127395.
Hoyer KK, French SW, Turner DE, et al. (2002). "Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma.". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14392-7. doi:10.1073/pnas.212410199. PMID 12381789.
French SW, Malone CS, Shen RR, et al. (2003). "Sp1 transactivation of the TCL1 oncogene.". J. Biol. Chem. 278 (2): 948-55. doi:10.1074/jbc.M207166200. PMID 12421830.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Herling M, Teitell MA, Shen RR, et al. (2004). "TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin.". Blood 101 (12): 5007-9. doi:10.1182/blood-2002-10-3297. PMID 12576313.
Kiss C, Nishikawa J, Takada K, et al. (2003). "T cell leukemia I oncogene expression depends on the presence of Epstein-Barr virus in the virus-carrying Burkitt lymphoma lines.". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4813-8. doi:10.1073/pnas.0730710100. PMID 12672960.