TCF7

From Wikipedia, the free encyclopedia

Transcription factor 7 (T-cell specific, HMG-box)

PDB rendering based on 2lef.

Available structures: 2lef

Identifiers

Symbol(s)

TCF7; MGC47735; TCF-1

External IDs

OMIM: 189908 MGI: 98507 HomoloGene: 2410

Gene ontology
Molecular Function:	• DNA binding • RNA polymerase II transcription factor activity
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription from RNA polymerase II promoter • immune response • Wnt receptor signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003202 (mRNA)
NP_003193 (protein)

NM_009331 (mRNA)
NP_033357 (protein)

Location

Chr 5: 133.48 - 133.51 Mb

Chr 11: 52.1 - 52.13 Mb

Pubmed search

[1]

[2]

Transcription factor 7 (T-cell specific, HMG-box), also known as TCF7, is a human gene.^[1]

[edit] References

^ Entrez Gene: TCF7 transcription factor 7 (T-cell specific, HMG-box).

[edit] Further reading

van de Wetering M, Oosterwegel M, Holstege F, et al. (1992). "The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization.". J. Biol. Chem. 267 (12): 8530-6. PMID 1569101.
van de Wetering M, Oosterwegel M, Dooijes D, Clevers H (1991). "Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box.". EMBO J. 10 (1): 123-32. PMID 1989880.
Castrop J, van Wichen D, Koomans-Bitter M, et al. (1995). "The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes.". Blood 86 (8): 3050-9. PMID 7579399.
Mayer K, Wolff E, Clevers H, Ballhausen WG (1995). "The human high mobility group (HMG)-box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA.". Biochim. Biophys. Acta 1263 (2): 169-72. PMID 7640309.
Van de Wetering M, Castrop J, Korinek V, Clevers H (1996). "Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties.". Mol. Cell. Biol. 16 (3): 745-52. PMID 8622675.
Korinek V, Barker N, Willert K, et al. (1998). "Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse.". Mol. Cell. Biol. 18 (3): 1248-56. PMID 9488439.
Roose J, Molenaar M, Peterson J, et al. (1998). "The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors.". Nature 395 (6702): 608-12. doi:10.1038/26989. PMID 9783587.
Roose J, Huls G, van Beest M, et al. (1999). "Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.". Science 285 (5435): 1923-6. PMID 10489374.
Brantjes H, Roose J, van De Wetering M, Clevers H (2001). "All Tcf HMG box transcription factors interact with Groucho-related co-repressors.". Nucleic Acids Res. 29 (7): 1410-9. PMID 11266540.
Batlle E, Henderson JT, Beghtel H, et al. (2002). "Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB.". Cell 111 (2): 251-63. PMID 12408869.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Noble JA, White AM, Lazzeroni LC, et al. (2003). "A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes.". Diabetes 52 (6): 1579-82. PMID 12765974.
Ioannidis V, Kunz B, Tanamachi DM, et al. (2003). "Initiation and limitation of Ly-49A NK cell receptor acquisition by T cell factor-1.". J. Immunol. 171 (2): 769-75. PMID 12847244.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Smit L, Baas A, Kuipers J, et al. (2004). "Wnt activates the Tak1/Nemo-like kinase pathway.". J. Biol. Chem. 279 (17): 17232-40. doi:10.1074/jbc.M307801200. PMID 14960582.
Smith SS, Patterson T, Pauza ME (2005). "Transgenic Ly-49A inhibits antigen-driven T cell activation and delays diabetes.". J. Immunol. 174 (7): 3897-905. PMID 15778344.
Willinger T, Freeman T, Herbert M, et al. (2006). "Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo.". J. Immunol. 176 (3): 1439-46. PMID 16424171.