TCF21 (gene)

From Wikipedia, the free encyclopedia

Transcription factor 21

Identifiers

External IDs

OMIM: 603306 MGI: 1202715 HomoloGene: 2414

Gene ontology
Molecular Function:	• DNA binding • RNA polymerase II transcription factor activity • protein binding
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • mesoderm development • sex differentiation • organ morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003206 (mRNA)
NP_003197 (protein)

NM_011545 (mRNA)
NP_035675 (protein)

Location

Chr 6: 134.25 - 134.26 Mb

Chr 10: 22.51 - 22.51 Mb

Pubmed search

[1]

[2]

Transcription factor 21, also known as TCF21, is a human gene.^[1]

TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: TCF21 transcription factor 21.

[edit] Further reading

Littlewood TD, Evan GI (1995). "Transcription factors 2: helix-loop-helix.". Protein profile 2 (6): 621-702. PMID 7553065.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Quaggin SE, Vanden Heuvel GB, Igarashi P (1998). "Pod-1, a mesoderm-specific basic-helix-loop-helix protein expressed in mesenchymal and glomerular epithelial cells in the developing kidney.". Mech. Dev. 71 (1-2): 37-48. PMID 9507058.
Hidai H, Bardales R, Goodwin R, et al. (1998). "Cloning of capsulin, a basic helix-loop-helix factor expressed in progenitor cells of the pericardium and the coronary arteries.". Mech. Dev. 73 (1): 33-43. PMID 9545526.
Robb L, Mifsud L, Hartley L, et al. (1999). "epicardin: A novel basic helix-loop-helix transcription factor gene expressed in epicardium, branchial arch myoblasts, and mesenchyme of developing lung, gut, kidney, and gonads.". Dev. Dyn. 213 (1): 105-13. doi:10.1002/(SICI)1097-0177(199809)213:1<105::AID-AJA10>3.0.CO;2-1. PMID 9733105.
Quaggin SE, Schwartz L, Cui S, et al. (2000). "The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis.". Development 126 (24): 5771-83. PMID 10572052.
Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758-65. doi:10.1101/gr.180101. PMID 11591653.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Funato N, Ohyama K, Kuroda T, Nakamura M (2003). "Basic helix-loop-helix transcription factor epicardin/capsulin/Pod-1 suppresses differentiation by negative regulation of transcription.". J. Biol. Chem. 278 (9): 7486-93. doi:10.1074/jbc.M212248200. PMID 12493738.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324-32. doi:10.1101/gr.2334104. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Smith LT, Lin M, Brena RM, et al. (2006). "Epigenetic regulation of the tumor suppressor gene TCF21 on 6q23-q24 in lung and head and neck cancer.". Proc. Natl. Acad. Sci. U.S.A. 103 (4): 982-7. doi:10.1073/pnas.0510171102. PMID 16415157.