TCF20

From Wikipedia, the free encyclopedia

Transcription factor 20 (AR1)

Identifiers

TCF20; AR1; KIAA0292; SPBP

External IDs

OMIM: 603107 MGI: 108399 HomoloGene: 4131

Gene ontology
Molecular Function:	• DNA binding • transcription coactivator activity • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_001128637 (mRNA)
XP_001128637 (protein)

NM_013836 (mRNA)
NP_038864 (protein)

Location

Chr 22: 40.89 - 40.94 Mb

Chr 15: 82.64 - 82.74 Mb

Pubmed search

[1]

[2]

Transcription factor 20 (AR1), also known as TCF20, is a human gene.^[1]

The protein encoded by this gene binds a platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 (stromelysin 1) promoter. The protein localizes to the nucleus and displays DNA-binding and transactivation activities. It is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Alternative splicing results in two transcript variants encoding different isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: TCF20 transcription factor 20 (AR1).

[edit] Further reading

Sanz L, Moscat J, Diaz-Meco MT (1995). "Molecular characterization of a novel transcription factor that controls stromelysin expression.". Mol. Cell. Biol. 15 (6): 3164-70. PMID 7760812.
Kirstein M, Sanz L, Quiñones S, et al. (1996). "Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene.". J. Biol. Chem. 271 (30): 18231-6. PMID 8663478.
Ohara O, Nagase T, Ishikawa K, et al. (1997). "Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins.". DNA Res. 4 (1): 53-9. PMID 9179496.
Rajadhyaksha A, Rivière M, Van Vooren P, et al. (1998). "Assignment of AR1, transcription factor 20 (TCF20), to human chromosome 22q13.3 with somatic cell hybrids and in situ hybridization.". Cytogenet. Cell Genet. 81 (3-4): 176-7. PMID 9730594.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489-95. doi:10.1038/990031. PMID 10591208.
Lyngsø C, Bouteiller G, Damgaard CK, et al. (2000). "Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers.". J. Biol. Chem. 275 (34): 26144-9. doi:10.1074/jbc.M003405200. PMID 10849425.
Rekdal C, Sjøttem E, Johansen T (2001). "The nuclear factor SPBP contains different functional domains and stimulates the activity of various transcriptional activators.". J. Biol. Chem. 275 (51): 40288-300. doi:10.1074/jbc.M006978200. PMID 10995766.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94-101. doi:10.1038/nbt1046. PMID 15592455.
Gburcik V, Bot N, Maggiolini M, Picard D (2005). "SPBP is a phosphoserine-specific repressor of estrogen receptor alpha.". Mol. Cell. Biol. 25 (9): 3421-30. doi:10.1128/MCB.25.9.3421-3430.2005. PMID 15831449.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Sjøttem E, Rekdal C, Svineng G, et al. (2007). "The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcription.". Nucleic Acids Res. 35 (19): 6648-62. doi:10.1093/nar/gkm739. PMID 17913746.