TCEA2

From Wikipedia, the free encyclopedia

Transcription elongation factor A (SII), 2

PDB rendering based on 1tfi.

Available structures: 1tfi

Identifiers

Symbol(s)

TCEA2; TFIIS

External IDs

OMIM: 604784 MGI: 107368 HomoloGene: 68304

Gene ontology
Molecular Function:	• DNA binding • RNA polymerase II transcription factor activity • transcription elongation regulator activity • translation elongation factor activity • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• nucleus • transcription elongation factor complex
Biological Process:	• transcription • RNA elongation • regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003195 (mRNA)
NP_003186 (protein)

NM_009326 (mRNA)
NP_033352 (protein)

Location

Chr 20: 62.16 - 62.17 Mb

Chr 2: 181.61 - 181.62 Mb

Pubmed search

[1]

[2]

Transcription elongation factor A (SII), 2, also known as TCEA2, is a human gene.^[1]

The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: TCEA2 transcription elongation factor A (SII), 2.

[edit] Further reading

Kato H, Sumimoto H, Pognonec P, et al. (1992). "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors.". Genes Dev. 6 (4): 655-66. PMID 1559613.
Umehara T, Kida S, Yamamoto T, Horikoshi M (1996). "Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II.". Gene 167 (1-2): 297-302. PMID 8566795.
Weaver ZA, Kane CM (1998). "Genomic characterization of a testis-specific TFIIS (TCEA2) gene.". Genomics 46 (3): 516-9. doi:10.1006/geno.1997.5073. PMID 9441762.
Li XY, Green MR (1998). "The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor.". Genes Dev. 12 (19): 2992-6. PMID 9765201.
Trembley JH, Hu D, Hsu LC, et al. (2002). "PITSLRE p110 protein kinases associate with transcription complexes and affect their activity.". J. Biol. Chem. 277 (4): 2589-96. doi:10.1074/jbc.M109755200. PMID 11709559.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
Sijbrandi R, Fiedler U, Timmers HT (2002). "RNA polymerase II complexes in the very early phase of transcription are not susceptible to TFIIS-induced exonucleolytic cleavage.". Nucleic Acids Res. 30 (11): 2290-8. PMID 12034815.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Saso K, Ito T, Natori S, Sekimizu K (2004). "Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II.". J. Biochem. 133 (4): 493-500. PMID 12761297.
Tamura K, Miyata K, Sugahara K, et al. (2003). "Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain.". Biochem. Biophys. Res. Commun. 309 (1): 189-95. PMID 12943681.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Nakata A, Ito T, Nagata M, et al. (2005). "GRIP1tau, a novel PDZ domain-containing transcriptional activator, cooperates with the testis-specific transcription elongation factor SII-T1.". Genes Cells 9 (11): 1125-35. doi:10.1111/j.1365-2443.2004.00795.x. PMID 15507123.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Palangat M, Renner DB, Price DH, Landick R (2005). "A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS.". Proc. Natl. Acad. Sci. U.S.A. 102 (42): 15036-41. doi:10.1073/pnas.0409405102. PMID 16214896.
Kuraoka I, Suzuki K, Ito S, et al. (2007). "RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS.". DNA Repair (Amst.) 6 (6): 841-51. doi:10.1016/j.dnarep.2007.01.014. PMID 17374514.