TBX19

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T-box 19
Identifiers
Symbol(s)	TBX19; FLJ26302; FLJ34543; TBS 19; TBS19; TPIT; dJ747L4.1
External IDs	OMIM: 604614 MGI: 1891158 HomoloGene: 3779
Gene ontology Molecular Function: • transcription factor activity • RNA polymerase II transcription factor activity • protein binding Cellular Component: • nucleus Biological Process: • transcription • regulation of transcription, DNA-dependent • regulation of transcription from RNA polymerase II promoter • anatomical structure morphogenesis • cell fate commitment
Orthologs
	Human	Mouse
Entrez	9095	83993
Ensembl	n/a	ENSMUSG00000026572
Uniprot	n/a	Q0VBH2
Refseq	NM_005149 (mRNA) NP_005140 (protein)	NM_032005 (mRNA) NP_114394 (protein)
Location	n/a	Chr 1: 166.97 - 167 Mb
Pubmed search	[1]	[2]

T-box 19, also known as TBX19, is a human gene.

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx19/Tpit gene. Studies in mouse show that Tpit protein is present only in the two pituitary pro-opiomelanocortin (POMC)-expressing lineages, the corticotrophs and melanotrophs. Mutations in the human ortholog were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage.^[1]

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