TBPL1

From Wikipedia, the free encyclopedia

TBP-like 1

Identifiers

TBPL1; TRF2; MGC:8389; MGC:9620; STUD; TLF; TLP

External IDs

OMIM: 605521 MGI: 1339946 HomoloGene: 3577

Gene ontology
Molecular Function:	• DNA binding • RNA polymerase II transcription factor activity • transcription coactivator activity • binding • protein binding
Cellular Component:	• nucleus • transcription factor TFIID complex • cytoplasm
Biological Process:	• acrosome formation • dTTP biosynthetic process • regulation of transcription, DNA-dependent • transcription initiation from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004865 (mRNA)
NP_004856 (protein)

NM_011603 (mRNA)
NP_035733 (protein)

Location

Chr 6: 134.32 - 134.35 Mb

Chr 10: 22.39 - 22.42 Mb

Pubmed search

[1]

[2]

TBP-like 1, also known as TBPL1, is a human gene.^[1]

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that serves the same function as TBP and substitutes for TBP at some promoters that are not recognized by TFIID. It is essential for spermiogenesis and believed to be important in expression of developmentally regulated genes.^[1]

[edit] References

^ ^a ^b Entrez Gene: TBPL1 TBP-like 1.

[edit] Further reading

Ohbayashi T, Makino Y, Tamura TA (1999). "Identification of a mouse TBP-like protein (TLP) distantly related to the drosophila TBP-related factor.". Nucleic Acids Res. 27 (3): 750–5. PMID 9889269.
Ohbayashi T, Kishimoto T, Makino Y, et al. (1999). "Isolation of cDNA, chromosome mapping, and expression of the human TBP-like protein.". Biochem. Biophys. Res. Commun. 255 (1): 137–42. PMID 10082669.
Rabenstein MD, Zhou S, Lis JT, Tjian R (1999). "TATA box-binding protein (TBP)-related factor 2 (TRF2), a third member of the TBP family.". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 4791–6. PMID 10220372.
Teichmann M, Wang Z, Martinez E, et al. (2000). "Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells.". Proc. Natl. Acad. Sci. U.S.A. 96 (24): 13720–5. PMID 10570139.
Martianov I, Brancorsini S, Gansmuller A, et al. (2002). "Distinct functions of TBP and TLF/TRF2 during spermatogenesis: requirement of TLF for heterochromatic chromocenter formation in haploid round spermatids.". Development 129 (4): 945–55. PMID 11861477.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Kieffer-Kwon P, Martianov I, Davidson I (2005). "Cell-specific nucleolar localization of TBP-related factor 2.". Mol. Biol. Cell 15 (10): 4356–68. doi:10.1091/mbc.E04-02-0138. PMID 15269281.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Chong JA, Moran MM, Teichmann M, et al. (2005). "TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP.". Mol. Cell. Biol. 25 (7): 2632–43. doi:10.1128/MCB.25.7.2632-2643.2005. PMID 15767669.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.