TBL1XR1

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Transducin (beta)-like 1X-linked receptor 1
Identifiers
Symbol(s) TBL1XR1; C21; DC42; FLJ12894; IRA1; TBLR1
External IDs MGI: 2441730 HomoloGene: 69382
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 79718 81004
Ensembl ENSG00000177565 ENSMUSG00000027630
Uniprot Q9BZK7 Q8BHJ5
Refseq NM_024665 (mRNA)
NP_078941 (protein)		 XM_977656 (mRNA)
XP_982750 (protein)
Location Chr 3: 178.22 - 178.4 Mb Chr 3: 22.27 - 22.4 Mb
Pubmed search [1] [2]

Transducin (beta)-like 1X-linked receptor 1, also known as TBL1XR1, is a human gene.[1]

The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation.[1]

[edit] References

  1. ^ a b Entrez Gene: TBL1XR1 transducin (beta)-like 1X-linked receptor 1.

[edit] Further reading

  • Zhang X, Dormady SP, Basch RS (2001). "Identification of four human cDNAs that are differentially expressed by early hematopoietic progenitors.". Exp. Hematol. 28 (11): 1286–96. PMID 11063877. 
  • Zhang J, Kalkum M, Chait BT, Roeder RG (2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2.". Mol. Cell 9 (3): 611–23. PMID 11931768. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Yoon HG, Chan DW, Huang ZQ, et al. (2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1.". EMBO J. 22 (6): 1336–46. doi:10.1093/emboj/cdg120. PMID 12628926. 
  • Yoon HG, Chan DW, Reynolds AB, et al. (2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso.". Mol. Cell 12 (3): 723–34. PMID 14527417. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Perissi V, Aggarwal A, Glass CK, et al. (2004). "A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors.". Cell 116 (4): 511–26. PMID 14980219. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Yoon HG, Choi Y, Cole PA, Wong J (2005). "Reading and function of a histone code involved in targeting corepressor complexes for repression.". Mol. Cell. Biol. 25 (1): 324–35. doi:10.1128/MCB.25.1.324-335.2005. PMID 15601853. 
  • Zhang XM, Chang Q, Zeng L, et al. (2006). "TBLR1 regulates the expression of nuclear hormone receptor co-repressors.". BMC Cell Biol. 7: 31. doi:10.1186/1471-2121-7-31. PMID 16893456. 
  • Liu Y, Sun W, Zhang K, et al. (2007). "Identification of genes differentially expressed in human primary lung squamous cell carcinoma.". Lung Cancer 56 (3): 307–17. doi:10.1016/j.lungcan.2007.01.016. PMID 17316888. 
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