TBCD

From Wikipedia, the free encyclopedia


Tubulin folding cofactor D
Identifiers
Symbol(s) TBCD; KIAA0988
External IDs OMIM: 604649 MGI: 1919686 HomoloGene: 4368
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6904 108903
Ensembl ENSG00000141556 ENSMUSG00000039230
Uniprot Q9BTW9 Q8R199
Refseq NM_001033052 (mRNA)
NP_001028224 (protein)		 NM_029878 (mRNA)
NP_084154 (protein)
Location Chr 17: 78.3 - 78.49 Mb Chr 11: 121.27 - 121.43 Mb
Pubmed search [1] [2]

Tubulin folding cofactor D, also known as TBCD, is a human gene.[1]

Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.[1]

[edit] References

  1. ^ a b Entrez Gene: TBCD tubulin folding cofactor D.

[edit] Further reading

  • Lewis SA, Tian G, Vainberg IE, Cowan NJ (1996). "Chaperonin-mediated folding of actin and tubulin.". J. Cell Biol. 132 (1-2): 1–4. PMID 8567715. 
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  • Tian G, Huang Y, Rommelaere H, et al. (1996). "Pathway leading to correctly folded beta-tubulin.". Cell 86 (2): 287–96. PMID 8706133. 
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174. 
  • Tian G, Lewis SA, Feierbach B, et al. (1997). "Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors.". J. Cell Biol. 138 (4): 821–32. PMID 9265649. 
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (1): 63–70. PMID 10231032. 
  • Martín L, Fanarraga ML, Aloria K, Zabala JC (2000). "Tubulin folding cofactor D is a microtubule destabilizing protein.". FEBS Lett. 470 (1): 93–5. PMID 10722852. 
  • Bhamidipati A, Lewis SA, Cowan NJ (2000). "ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin.". J. Cell Biol. 149 (5): 1087–96. PMID 10831612. 
  • Schubert A, Cattaruzza M, Hecker M, et al. (2001). "Shear stress-dependent regulation of the human beta-tubulin folding cofactor D gene.". Circ. Res. 87 (12): 1188–94. PMID 11110777. 
  • Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.". Mol. Vis. 8: 205–20. PMID 12107410. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Shern JF, Sharer JD, Pallas DC, et al. (2003). "Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A.". J. Biol. Chem. 278 (42): 40829–36. doi:10.1074/jbc.M308678200. PMID 12912990. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
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