TBCA

From Wikipedia, the free encyclopedia

Tubulin folding cofactor A

PDB rendering based on 1h7c.

Available structures: 1h7c

Identifiers

Symbol(s)

TBCA;

External IDs

OMIM: 610058 MGI: 107549 HomoloGene: 3388

Gene ontology
Molecular Function:	• unfolded protein binding • chaperone binding
Cellular Component:	• cytoplasm • cytoskeleton • microtubule
Biological Process:	• protein folding • chaperonin-mediated tubulin folding • post-chaperonin tubulin folding pathway • beta-tubulin folding

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_004607 (mRNA)
NP_004598 (protein)

NM_009321 (mRNA)
NP_033347 (protein)

Location

Chr 5: 77.02 - 77.11 Mb

n/a

Pubmed search

[1]

[2]

Tubulin folding cofactor A, also known as TBCA, is a human gene.^[1]

The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A.^[1]

[edit] References

^ ^a ^b Entrez Gene: TBCA tubulin folding cofactor A.

[edit] Further reading

Lewis SA, Tian G, Vainberg IE, Cowan NJ (1996). "Chaperonin-mediated folding of actin and tubulin.". J. Cell Biol. 132 (1-2): 1-4. PMID 8567715.
Tian G, Huang Y, Rommelaere H, et al. (1996). "Pathway leading to correctly folded beta-tubulin.". Cell 86 (2): 287-96. PMID 8706133.
Mao M, Fu G, Wu JS, et al. (1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175-80. PMID 9653160.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546-60. PMID 11042152.
Guasch A, Aloria K, Pérez R, et al. (2002). "Three-dimensional structure of human tubulin chaperone cofactor A.". J. Mol. Biol. 318 (4): 1139-49. doi:10.1016/S0022-2836(02)00185-7. PMID 12054808.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Nolasco S, Bellido J, Gonçalves J, et al. (2005). "Tubulin cofactor A gene silencing in mammalian cells induces changes in microtubule cytoskeleton, cell cycle arrest and cell death.". FEBS Lett. 579 (17): 3515-24. doi:10.1016/j.febslet.2005.05.022. PMID 15963512.
Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.". Proteomics 5 (15): 3876-84. doi:10.1002/pmic.200401239. PMID 16130169.