TBC1D3

From Wikipedia, the free encyclopedia


TBC1 domain family, member 3
Identifiers
Symbol(s) TBC1D3; TRE17; TBC1D3A; PRC17; MGC44903
External IDs OMIM: 607741 HomoloGene: 74280
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 84218 n/a
Ensembl ENSG00000189309 n/a
Refseq NM_032258 (mRNA)
NP_115634 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 17: 31.52 - 31.53 Mb n/a
Pubmed search [1] n/a

TBC1 domain family, member 3, also known as TBC1D3, is a human gene.[1]

This gene encodes a protein that is similar to TBC1 domain family, member 3. This protein contains a TBC (Tre-2, Bub2p, and Cdc16p) domain, which is found in proteins involved in RAB GTPase signaling and vesicle trafficking. There are two copies of this gene located within a cluster of chemokine genes on chromosome 17q; this record represents the more centromeric copy.[1]

[edit] References

  1. ^ a b Entrez Gene: TBC1D3 TBC1 domain family, member 3.

[edit] Further reading

  • Onno M, Nakamura T, Hillova J, Hill M (1993). "Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes.". Gene 131 (2): 209–15. PMID 8406013. 
  • Onno M, Nakamura T, Mariage-Samson R, et al. (1993). "Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes.". DNA Cell Biol. 12 (2): 107–18. PMID 8471161. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863. 
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Paulding CA, Ruvolo M, Haber DA (2003). "The Tre2 (USP6) oncogene is a hominoid-specific gene.". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2507–11. doi:10.1073/pnas.0437015100. PMID 12604796. 
  • Masuda-Robens JM, Kutney SN, Qi H, Chou MM (2003). "The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling.". Mol. Cell. Biol. 23 (6): 2151–61. PMID 12612085. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336. 
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901. 
  • Hodzic D, Kong C, Wainszelbaum MJ, et al. (2007). "TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.". Genomics 88 (6): 731–6. doi:10.1016/j.ygeno.2006.05.009. PMID 16863688. 
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