Taxadiene 5alpha-hydroxylase

From Wikipedia, the free encyclopedia

In enzymology, a taxadiene 5alpha-hydroxylase (EC 1.14.99.37) is an enzyme that catalyzes the chemical reaction

taxa-4,11-diene + AH₂ + O₂ taxa-4(20),11-dien-5alpha-ol + A + H₂O

The 3 substrates of this enzyme are taxa-4,11-diene, AH2, and O₂, whereas its 3 products are taxa-4(20),11-dien-5alpha-ol, A, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is taxa-4,11-diene,hydrogen-donor:oxygen oxidoreductase (5alpha-hydroxylating). This enzyme participates in diterpenoid biosynthesis.

[edit] References

• IUBMB entry for 1.14.99.37
• BRENDA references for 1.14.99.37 (Recommended.)
• PubMed references for 1.14.99.37
• PubMed Central references for 1.14.99.37
• Google Scholar references for 1.14.99.37
• R (1996). "Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5alpha-ol: the first oxygenation step in taxol biosynthesis". Chem. Biol. 3: 479–89. doi:10.1016/S1074-5521(96)90096-4. PMID 8807878. 

[edit] External links

The CAS registry number for this enzyme class is 9035-51-2.

• IUBMB entry for 1.14.99.37

• KEGG entry for 1.14.99.37

• BRENDA entry for 1.14.99.37

• NiceZyme view of 1.14.99.37

• EC2PDB: PDB structures for 1.14.99.37

• PRIAM entry for 1.14.99.37

• PUMA2 entry for 1.14.99.37

• IntEnz: Integrated Enzyme entry for 1.14.99.37

• MetaCyc entry for 1.14.99.37

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050604: taxadiene 5-alpha-hydroxylase

• AMIGO entry for GO code 0050604: taxadiene 5-alpha-hydroxylase