TAS2R4
From Wikipedia, the free encyclopedia
Taste receptor, type 2, member 4
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Identifiers | ||||||||||||||
Symbol(s) | TAS2R4; MGC163311; T2R4 | |||||||||||||
External IDs | OMIM: 604869 MGI: 2681210 HomoloGene: 49480 | |||||||||||||
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RNA expression pattern | ||||||||||||||
Orthologs | ||||||||||||||
Human | Mouse | |||||||||||||
Entrez | 50832 | 57253 | ||||||||||||
Ensembl | ENSG00000127364 | ENSMUSG00000037140 | ||||||||||||
Uniprot | Q9NYW5 | Q9JKT3 | ||||||||||||
Refseq | NM_016944 (mRNA) NP_058640 (protein) |
NM_020502 (mRNA) NP_065248 (protein) |
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Location | Chr 7: 141.12 - 141.13 Mb | Chr 6: 40.42 - 40.42 Mb | ||||||||||||
Pubmed search | [1] | [2] |
Taste receptor, type 2, member 4, also known as TAS2R4, is a human gene.[1]
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception.[1]
[edit] See also
[edit] References
[edit] Further reading
- Kinnamon SC (2000). "A plethora of taste receptors.". Neuron 25 (3): 507–10. PMID 10774719.
- Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction.". J. Biol. Chem. 277 (1): 1–4. doi: . PMID 11696554.
- Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste.". Curr. Opin. Neurobiol. 12 (4): 366–71. PMID 12139982.
- Adler E, Hoon MA, Mueller KL, et al. (2000). "A novel family of mammalian taste receptors.". Cell 100 (6): 693–702. PMID 10761934.
- Chandrashekar J, Mueller KL, Hoon MA, et al. (2000). "T2Rs function as bitter taste receptors.". Cell 100 (6): 703–11. PMID 10761935.
- Firestein S (2000). "The good taste of genomics.". Nature 404 (6778): 552–3. doi: . PMID 10766221.
- Matsunami H, Montmayeur JP, Buck LB (2000). "A family of candidate taste receptors in human and mouse.". Nature 404 (6778): 601–4. doi: . PMID 10766242.
- Ueda T, Ugawa S, Ishida Y, et al. (2001). "Identification of coding single-nucleotide polymorphisms in human taste receptor genes involving bitter tasting.". Biochem. Biophys. Res. Commun. 285 (1): 147–51. doi: . PMID 11437385.
- Zhang Y, Hoon MA, Chandrashekar J, et al. (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.". Cell 112 (3): 293–301. PMID 12581520.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi: . PMID 12853948.
- Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes.". Mol. Biol. Evol. 22 (3): 432–6. doi: . PMID 15496549.
- Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.". Genetics 170 (1): 313–26. doi: . PMID 15744053.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.