TAS2R4

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Taste receptor, type 2, member 4
Identifiers
Symbol(s) TAS2R4; MGC163311; T2R4
External IDs OMIM: 604869 MGI2681210 HomoloGene49480
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 50832 57253
Ensembl ENSG00000127364 ENSMUSG00000037140
Uniprot Q9NYW5 Q9JKT3
Refseq NM_016944 (mRNA)
NP_058640 (protein)
NM_020502 (mRNA)
NP_065248 (protein)
Location Chr 7: 141.12 - 141.13 Mb Chr 6: 40.42 - 40.42 Mb
Pubmed search [1] [2]

Taste receptor, type 2, member 4, also known as TAS2R4, is a human gene.[1]

This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception.[1]

[edit] See also

[edit] References

[edit] Further reading

  • Kinnamon SC (2000). "A plethora of taste receptors.". Neuron 25 (3): 507–10. PMID 10774719. 
  • Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction.". J. Biol. Chem. 277 (1): 1–4. doi:10.1074/jbc.R100054200. PMID 11696554. 
  • Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste.". Curr. Opin. Neurobiol. 12 (4): 366–71. PMID 12139982. 
  • Adler E, Hoon MA, Mueller KL, et al. (2000). "A novel family of mammalian taste receptors.". Cell 100 (6): 693–702. PMID 10761934. 
  • Chandrashekar J, Mueller KL, Hoon MA, et al. (2000). "T2Rs function as bitter taste receptors.". Cell 100 (6): 703–11. PMID 10761935. 
  • Firestein S (2000). "The good taste of genomics.". Nature 404 (6778): 552–3. doi:10.1038/35007167. PMID 10766221. 
  • Matsunami H, Montmayeur JP, Buck LB (2000). "A family of candidate taste receptors in human and mouse.". Nature 404 (6778): 601–4. doi:10.1038/35007072. PMID 10766242. 
  • Ueda T, Ugawa S, Ishida Y, et al. (2001). "Identification of coding single-nucleotide polymorphisms in human taste receptor genes involving bitter tasting.". Biochem. Biophys. Res. Commun. 285 (1): 147–51. doi:10.1006/bbrc.2001.5136. PMID 11437385. 
  • Zhang Y, Hoon MA, Chandrashekar J, et al. (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.". Cell 112 (3): 293–301. PMID 12581520. 
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. 
  • Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes.". Mol. Biol. Evol. 22 (3): 432–6. doi:10.1093/molbev/msi027. PMID 15496549. 
  • Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.". Genetics 170 (1): 313–26. doi:10.1534/genetics.104.037523. PMID 15744053. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.