TAS1R3

From Wikipedia, the free encyclopedia

Taste receptor, type 1, member 3

Identifiers

External IDs

OMIM: 605865 MGI: 1933547 HomoloGene: 12890

Gene ontology
Molecular Function:	• receptor activity • metabotropic glutamate, GABA-B-like receptor activity • taste receptor activity • protein heterodimerization activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• signal transduction • G-protein coupled receptor protein signaling pathway • response to stimulus • sensory perception of sweet taste • sensory perception of umami taste

Orthologs

Human

Mouse

Refseq

NM_152228 (mRNA)
NP_689414 (protein)

NM_031872 (mRNA)
NP_114078 (protein)

Location

Chr 1: 1.26 - 1.26 Mb

Chr 4: 154.7 - 154.71 Mb

Pubmed search

[1]

[2]

Taste receptor, type 1, member 3, also known as TAS1R3, is a human gene.^[1]

The TAS1R3 gene encodes the human homolog of mouse Sac, a major determinant of differences between sweet-sensitive and -insensitive mouse strains in their responsiveness to sucrose, saccharin, and other sweeteners.[supplied by OMIM]^[1]

[edit] See also

Taste receptor

[edit] References

^ ^a ^b Entrez Gene: TAS1R3 taste receptor, type 1, member 3.

[edit] Further reading

Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS (2007). "The receptors and cells for mammalian taste.". Nature 444 (7117): 288–94. doi:10.1038/nature05401. PMID 17108952.
Montmayeur JP, Liberles SD, Matsunami H, Buck LB (2001). "A candidate taste receptor gene near a sweet taste locus.". Nat. Neurosci. 4 (5): 492–8. doi:10.1038/87440. PMID 11319557.
Max M, Shanker YG, Huang L, et al. (2001). "Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac.". Nat. Genet. 28 (1): 58–63. doi:10.1038/88270. PMID 11326277.
Nelson G, Chandrashekar J, Hoon MA, et al. (2002). "An amino-acid taste receptor.". Nature 416 (6877): 199–202. doi:10.1038/nature726. PMID 11894099.
Li X, Staszewski L, Xu H, et al. (2002). "Human receptors for sweet and umami taste.". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4692–6. doi:10.1073/pnas.072090199. PMID 11917125.
Spadaccini R, Trabucco F, Saviano G, et al. (2003). "The mechanism of interaction of sweet proteins with the T1R2-T1R3 receptor: evidence from the solution structure of G16A-MNEI.". J. Mol. Biol. 328 (3): 683–92. PMID 12706725.
Ariyasu T, Matsumoto S, Kyono F, et al. (2004). "Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose.". In Vitro Cell. Dev. Biol. Anim. 39 (1-2): 80–8. doi:10.1290/1543-706X(2003)039<0080:TRTIAE>2.0.CO;2. PMID 12892531.
Jiang P, Ji Q, Liu Z, et al. (2004). "The cysteine-rich region of T1R3 determines responses to intensely sweet proteins.". J. Biol. Chem. 279 (43): 45068–75. doi:10.1074/jbc.M406779200. PMID 15299024.
Xu H, Staszewski L, Tang H, et al. (2005). "Different functional roles of T1R subunits in the heteromeric taste receptors.". Proc. Natl. Acad. Sci. U.S.A. 101 (39): 14258–63. doi:10.1073/pnas.0404384101. PMID 15353592.
Taniguchi K (2005). "Expression of the sweet receptor protein, T1R3, in the human liver and pancreas.". J. Vet. Med. Sci. 66 (11): 1311–4. PMID 15585941.
Jiang P, Cui M, Zhao B, et al. (2005). "Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste.". J. Biol. Chem. 280 (15): 15238–46. doi:10.1074/jbc.M414287200. PMID 15668251.
Galindo-Cuspinera V, Winnig M, Bufe B, et al. (2006). "A TAS1R receptor-based explanation of sweet 'water-taste'.". Nature 441 (7091): 354–7. doi:10.1038/nature04765. PMID 16633339.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Behrens M, Bartelt J, Reichling C, et al. (2006). "Members of RTP and REEP gene families influence functional bitter taste receptor expression.". J. Biol. Chem. 281 (29): 20650–9. doi:10.1074/jbc.M513637200. PMID 16720576.
Koizumi A, Nakajima K, Asakura T, et al. (2007). "Taste-modifying sweet protein, neoculin, is received at human T1R3 amino terminal domain.". Biochem. Biophys. Res. Commun. 358 (2): 585–9. doi:10.1016/j.bbrc.2007.04.171. PMID 17499612.

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v • d • e Transmembrane receptor: G protein-coupled receptors

Class A: Rhodopsin like	Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)

Class B: Secretin like	Brain-specific angiogenesis inhibitor (1, 2, 3) - Cadherin (1, 2, 3) - Calcitonin - CD97 - Corticotropin-releasing hormone (1, 2) - EMR (1, 2, 3) - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - PACAPR1- GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) - Latrophilin (1, 2, 3, ELTD1) - Parathyroid hormone (1, 2) - Secretin - Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic glutamate / pheromone	Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))

Frizzled / Smoothened	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened